SYNTHESIS, ANTINOCICEPTIVE ACTIVITY AND OPIOID RECEPTOR PROFILES OF 3-(OCTAHYDRO-1H-PYRANO[4,3-C]PYRIDIN-8A-YL AND OCTAHYDRO-1H-THIOPYRANO[4,3-C]PYRIDIN-8A-YL)PHENOLS

被引：7
作者：
BAYS, DE
BROWN, DS
BELTON, DJ
LLOYD, JE
MCELROY, AB
MEERHOLZ, CA
SCOPES, DIC
BIRCH, PJ
HAYES, AG
SHEEHAN, MJ
机构：
[1] GLAXO GRP RES LTD,CHEM RES DEPT,WARE SG12 0DJ,HERTS,ENGLAND
[2] GLAXO GRP RES LTD,DEPT NEUROPHARMACOL,WARE SG12 0DJ,HERTS,ENGLAND
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1989年 / 07期
关键词：
D O I：
10.1039/p19890001177
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
引用
收藏
页码：1177 / 1186
页数：10
相关论文
共 29 条
[1]  
BELLEAU R, 1982, CHEM REGULATION BIOL, P200
[2]  
BELLEAU R, 1981, DRUGS FUTURE, V6, P632
[3]  
Casy A. F., 1986, OPIOID ANALGESICS CH
[4]   ABDOMINAL CONSTRICTION RESPONSE AND ITS SUPPRESSION BY ANALGESIC DRUGS IN MOUSE [J].
COLLIER, HOJ ;
DINNEEN, LC ;
JOHNSON, CA ;
SCHNEIDER, C .
BRITISH JOURNAL OF PHARMACOLOGY, 1968, 32 (02) :295-+
[5]   INVIVO STUDIES ON KAPPA-OPIOID RECEPTORS [J].
COWAN, A ;
GMEREK, DE .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1986, 7 (02) :69-72
[6]   APPLICATION OF METALATED ENAMINES TO ALKALOID SYNTHESIS - AN EXPEDIENT APPROACH TO THE SYNTHESIS OF MORPHINE-BASED ANALGESICS [J].
EVANS, DA ;
MITCH, CH ;
THOMAS, RC ;
ZIMMERMAN, DM ;
ROBEY, RL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (18) :5955-5956
[7]   A SHORT, STEREOSPECIFIC SYNTHESIS OF A MORPHINE FRAGMENT VIA AN INTRAMOLECULAR DIELS-ALDER REACTION [J].
HANDA, S ;
JONES, K ;
NEWTON, CG ;
WILLIAMS, DJ .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1985, (19) :1362-1363
[8]   PROFILE OF ACTIVITY OF KAPPA-RECEPTOR AGONISTS IN THE RABBIT VAS-DEFERENS [J].
HAYES, A ;
KELLY, A .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 110 (03) :317-322
[9]   DETERMINATION OF THE RECEPTOR SELECTIVITY OF OPIOID AGONISTS IN THE GUINEA-PIG ILEUM AND MOUSE VAS-DEFERENS BY USE OF BETA-FUNALTREXAMINE [J].
HAYES, AG ;
SHEEHAN, MJ ;
TYERS, MB .
BRITISH JOURNAL OF PHARMACOLOGY, 1985, 86 (04) :899-904
[10]   DIFFERENTIAL SENSITIVITY OF MODELS OF ANTINOCICEPTION IN THE RAT, MOUSE AND GUINEA-PIG TO MU-OPIOID AND KAPPA-OPIOID RECEPTOR AGONISTS [J].
HAYES, AG ;
SHEEHAN, MJ ;
TYERS, MB .
BRITISH JOURNAL OF PHARMACOLOGY, 1987, 91 (04) :823-832
123