COSTS, EFFECTS AND C/E-RATIOS ALONGSIDE A CLINICAL-TRIAL

被引:717
作者
VANHOUT, BA
AL, MJ
GORDON, GS
RUTEN, FFH
机构
[1] UNIV COLORADO,HLTH SCI CTR,DENVER,CO 80262
[2] SYNERGEN INC,BOULDER,CO
关键词
ECONOMIC APPRAISAL; CONFIDENCE INTERVALS; COST EFFECTIVENESS RATIO; RHIL-1RA; ANAKINRA; SEPSIS SYNDROME;
D O I
10.1002/hec.4730030505
中图分类号
F [经济];
学科分类号
02 ;
摘要
A general approach is discussed to assess the uncertainty surrounding the cost effectiveness ratio (C/E-ratio) estimated on the basis of data from a randomised clinical trial. The approach includes the calculation of a 95% probability ellipse and introduces the concept of a so called C/E-acceptability curve. This last curve defines for each predefined C/E-ratio the probability that the C/E-ratio found in the study is acceptable. The approach is illustrated by estimates of costs per life saved and costs per patient discharged alive on the basis of data from a phase II trial addressing the value of anakinra in treating sepsis syndrome.
引用
收藏
页码:309 / 319
页数:11
相关论文
共 18 条
  • [1] [Anonymous], 1987, GUIDE SIMULATION
  • [2] THE CE PLANE - A GRAPHIC REPRESENTATION OF COST-EFFECTIVENESS
    BLACK, WC
    [J]. MEDICAL DECISION MAKING, 1990, 10 (03) : 212 - 214
  • [3] *COMM AUSTR, 1992, GUID PHARM IND PREP, P13
  • [4] Fieller EC, 1932, BIOMETRIKA, V24, P428, DOI 10.2307/2331976
  • [5] INITIAL EVALUATION OF HUMAN RECOMBINANT INTERLEUKIN-1 RECEPTOR ANTAGONIST IN THE TREATMENT OF SEPSIS SYNDROME - A RANDOMIZED, OPEN-LABEL, PLACEBO-CONTROLLED MULTICENTER TRIAL
    FISHER, CJ
    SLOTMAN, GJ
    OPAL, SM
    PRIBBLE, JP
    BONE, RC
    EMMANUEL, G
    NG, D
    BLOEDOW, DC
    CATALANO, MA
    FRIEDMAN, B
    MURE, A
    SHAPIRO, E
    [J]. CRITICAL CARE MEDICINE, 1994, 22 (01) : 12 - 21
  • [6] The frequency distribution of the quotient of two normal variates
    Geary, RC
    [J]. JOURNAL OF THE ROYAL STATISTICAL SOCIETY, 1930, 93 : 442 - 446
  • [7] GNEDENKO BV, 1986, THEORY PROBABILITY
  • [8] GORDON GS, 1992, CLIN RES, V40, pA254
  • [9] HILGEMAN CN, 1992, IMTA9217 ER U ROTT R
  • [10] LAUPACIS A, 1992, CAN MED ASSOC J, V146, P473