ATP SYNTHASE - STRUCTURE-FUNCTION-RELATIONSHIPS

被引：7

作者：

THOMAS, PJ

BIANCHET, M

GARBOCZI, DN

HULLIHEN, J

AMZEL, LM

PEDERSEN, PL

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT BIOL CHEM,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT BIOPHYS & PHYS CHEM,BALTIMORE,MD 21205

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1101卷 / 02期

关键词：

ATP SYNTHESIS; ATP SYNTHASE; ATPASE; F1-;

D O I：

10.1016/S0005-2728(05)80027-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent work has focused on obtaining a better understanding of the three-dimensional structural relationships between the alpha and beta subunits of the F1 moiety and the location of nucleotide binding domains within these subunits. Four types of approach are currently being pursued: X-ray crystallographic, chemical, molecular biological and biochemical. Here we briefly review some of the major conclusions of these studies, and point out some of the problems that must be resolved before an adequate model that relates structure to function in the ATP synthase molecule can be formulated.

引用

页码：228 / 231

页数：4

共 23 条

[1]

AMZEL LM, 1978, J BIOL CHEM, V253, P2067

[2]

BIANCHET M, 1991, J BIOL CHEM, V266, P21197

[3] PHOTOAFFINITY-LABELING OF MITOCHONDRIAL ADENOSINE-TRIPHOSPHATASE BY 2-AZIDOADENOSINE 5'-[ALPHA-P-32]DIPHOSPHATE [J].