SUPPRESSION OF TUMORIGENICITY IN WILMS-TUMOR BY THE P15.5-P14 REGION OF CHROMOSOME-11

被引：135

作者：

DOWDY, SF

FASCHING, CL

ARAUJO, D

LAI, KM

LIVANOS, E

WEISSMAN, BE

STANBRIDGE, EJ

机构：

[1] UNIV CALIF IRVINE,DEPT MICROBIOL & MOLEC GENET,IRVINE,CA 92717

[2] UNIV N CAROLINA,LINEBERGER CANC RES CTR,CHAPEL HILL,NC 27599

来源：

SCIENCE | 1991年 / 254卷 / 5029期

关键词：

D O I：

10.1126/science.1656527

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wilms tumor has been associated with genomic alterations at both the 11p13 and 11p15 regions. To differentiate between the involvement of these two loci, a chromosome 11 was constructed that had one or the other region deleted, and this chromosome was introduced into the tumorigenic Wilms tumor cell line G401. When assayed for tumor-forming activity in nude mice, the 11p13-deleted, but not the 11p15.5-p14.1-deleted chromosome, retained its ability to suppress tumor formation. These results provide in vivo functional evidence for the existence of a second genetic locus (WT2) involved in suppressing the tumorigenic phenotype of Wilms tumor.

引用

收藏

页码：293 / 295

页数：3

相关论文

共 41 条

[1] REDUCTION TO HOMOZYGOSITY OF GENES ON CHROMOSOME-11 IN HUMAN-BREAST NEOPLASIA [J].

ALI, IU ;

LIDEREAU, R ;

THEILLET, C ;

CALLAHAN, R .

SCIENCE, 1987, 238 (4824) :185-188

[2] WILMS TUMOR AND OTHER RENAL TUMORS OF CHILDHOOD - A SELECTIVE REVIEW FROM THE NATIONAL-WILMS-TUMOR-STUDY-PATHOLOGY-CENTER [J].

BECKWITH, JB .

HUMAN PATHOLOGY, 1983, 14 (06) :481-492

[3] WIEDEMANN-BECKWITH SYNDROME - AUTOSOMAL-DOMINANT INHERITANCE IN A FAMILY [J].

BEST, LG ;

HOEKSTRA, RE .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1981, 9 (04) :291-299

[4] LOSS OF CHROMOSOME-11P ALLELES IN CULTURED-CELLS DERIVED FROM WILMS-TUMORS [J].

BROWN, KW ;

SHAW, APW ;

POIRIER, V ;

TYLER, SJ ;

BERRY, PJ ;

MOTT, MG ;

MAITLAND, NJ .

BRITISH JOURNAL OF CANCER, 1989, 60 (01) :25-29

[5] ISOLATION AND CHARACTERIZATION OF A ZINC FINGER POLYPEPTIDE GENE AT THE HUMAN CHROMOSOME-11 WILMS TUMOR LOCUS [J].

CALL, KM ;

GLASER, T ;

ITO, CY ;

BUCKLER, AJ ;

PELLETIER, J ;

HABER, DA ;

ROSE, EA ;

KRAL, A ;

YEGER, H ;

LEWIS, WH ;

JONES, C ;

HOUSMAN, DE .

CELL, 1990, 60 (03) :509-520

[6] DEFINITION OF THE LIMITS OF THE WILMS TUMOR LOCUS ON HUMAN CHROMOSOME-11P13 [J].

COMPTON, DA ;

WEIL, MM ;

BONETTA, L ;

HUANG, A ;

JONES, C ;

YEGER, H ;

WILLIAMS, BRG ;

STRONG, LC ;

SAUNDERS, GF .

GENOMICS, 1990, 6 (02) :309-315

[7] 4 NEW DNA MARKERS ARE ASSIGNED TO THE WAGR REGION OF 11P13 - ISOLATION AND REGIONAL ASSIGNMENT OF 112 CHROMOSOME-11 ANONYMOUS DNA SEGMENTS [J].

DAVIS, LM ;

BYERS, MG ;

FUKUSHIMA, Y ;

QIN, S ;

NOWAK, NJ ;

SCOGGIN, C ;

SHOWS, TB .

GENOMICS, 1988, 3 (03) :264-271

[8] IRRADIATION MICROCELL-MEDIATED CHROMOSOME TRANSFER (XMMCT) - THE GENERATION OF SPECIFIC CHROMOSOMAL ARM DELETIONS [J].

DOWDY, SF ;

SCANLON, DJ ;

FASCHING, CL ;

CASEY, G ;

STANBRIDGE, EJ .

GENES CHROMOSOMES & CANCER, 1990, 2 (04) :318-327

[9]

DOWDY SF, UNPUB

[10] LOSS OF GENES ON THE SHORT ARM OF CHROMOSOME-11 IN BLADDER-CANCER [J].

FEARON, ER ;

FEINBERG, AP ;

HAMILTON, SH ;

VOGELSTEIN, B .

NATURE, 1985, 318 (6044) :377-380

← 1 2 3 4 5 →