THE EFFECT OF DELTA-SLEEP-INDUCING PEPTIDE (DSIP) ON THE CHANGES OF BODY (CORE) TEMPERATURE-INDUCED BY SEROTONERGIC AGONISTS IN RATS

被引：3
作者：
TSUNASHIMA, K
KATO, N
MASUI, A
TAKAHASHI, K
机构：
[1] NATL CTR NEUROL & PSYCHIAT,DIV MENTAL DISORDERS RES,KODAIRA,TOKYO 187,JAPAN
[2] SHIGA UNIV MED SCI,DEPT PSYCHIAT,OTSU,SHIGA 52021,JAPAN
来源：
PEPTIDES | 1994年 / 15卷 / 01期
关键词：
DELTA SLEEP-INDUCING PEPTIDE (DSIP); HYPOTHERMIA; 5-METHOXY-N; N-DIMETHYL-TRYPTAMINE; (5-MEODMT); 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN (8-OH-DPAT); APOMORPHINE; PINDOLOL;
D O I：
10.1016/0196-9781(94)90171-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hyperthermia induced by high doses of 5-methoxy-N,N-dimethyl-tryptamine (5-MeODMT) was diminished and hypothermia induced by low doses of 5-MeODMT was enhanced by pretreatment with delta sleep-inducing peptide (DSIP). Delta sleep-inducing peptide had an enhancing effect of hypothermia induced by 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). This action of DSIP was completely inhibited by ICV injection of anti-DSIP. Pindolol prevented the enhancing action of DSIP on both 8-OH-DPAT- and apomorphine-induced hypothermia. It is suggested that the thermoregulatory action of DSIP is primarily exerted by a 5-HT1A mechanism in the rat.
引用
收藏
页码：61 / 65
页数：5
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