THE CLONING OF A FAMILY OF GENES THAT ENCODE THE MELANOCORTIN RECEPTORS

被引：1432
作者：
MOUNTJOY, KG
ROBBINS, LS
MORTRUD, MT
CONE, RD
机构：
[1] OREGON HLTH SCI UNIV,VOLLUM INST ADV BIOMED RES,PORTLAND,OR 97201
[2] OREGON HLTH SCI UNIV,DEPT CELL BIOL & ANAT,PORTLAND,OR 97201
[3] OREGON HLTH SCI UNIV,DEPT BIOCHEM & MOLEC BIOL,PORTLAND,OR 97201
来源：
SCIENCE | 1992年 / 257卷 / 5074期
关键词：
D O I：
10.1126/science.1325670
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) regulate pigmentation and adrenal cortical function, respectively. These peptides also have a variety of biological activities in other areas, including the brain, the pituitary, and the immune system. A complete understanding of the biological activities of these hormones requires the isolation and characterization of their corresponding receptors. The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor.
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页码：1248 / 1251
页数：4
相关论文
共 37 条
[1]   MOLECULAR-BIOLOGY OF THE VISUAL PIGMENTS [J].
APPLEBURY, ML ;
HARGRAVE, PA .
VISION RESEARCH, 1986, 26 (12) :1881-+
[2]   CHARACTERIZATION OF CORTICOTROPIN RECEPTORS ON ADRENOCORTICAL-CELLS [J].
BUCKLEY, DI ;
RAMACHANDRAN, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (12) :7431-7435
[3]  
CANNON JG, 1986, J IMMUNOL, V137, P2232
[4]   HIGH-EFFICIENCY TRANSFORMATION OF MAMMALIAN-CELLS BY PLASMID DNA [J].
CHEN, C ;
OKAYAMA, H .
MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (08) :2745-2752
[5]  
CHIRGWIN JM, 1979, BIOCHEMISTRY-US, V18, P5924
[6]   A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX [J].
DEVEREUX, J ;
HAEBERLI, P ;
SMITHIES, O .
NUCLEIC ACIDS RESEARCH, 1984, 12 (01) :387-395
[7]  
DEWIED D, 1982, PHYSIOL REV, V62, P977
[8]   STRUCTURAL FEATURES REQUIRED FOR LIGAND-BINDING TO THE BETA-ADRENERGIC-RECEPTOR [J].
DIXON, RAF ;
SIGAL, IS ;
CANDELORE, MR ;
REGISTER, RB ;
SCATTERGOOD, W ;
RANDS, E ;
STRADER, CD .
EMBO JOURNAL, 1987, 6 (11) :3269-3275
[9]   ALPHA-MELANOCYTE-STIMULATING HORMONE IS A MAMMOTROPIC FACTOR RELEASED BY NEUROINTERMEDIATE LOBE CELLS AFTER ESTROGEN-TREATMENT [J].
ELLERKMANN, E ;
NAGY, GM ;
FRAWLEY, LS .
ENDOCRINOLOGY, 1992, 130 (01) :133-138
[10]   NUCLEOTIDE-SEQUENCE OF A HUMAN CANNABINOID RECEPTOR CDNA [J].
GERARD, C ;
MOLLEREAU, C ;
VASSART, G ;
PARMENTIER, M .
NUCLEIC ACIDS RESEARCH, 1990, 18 (23) :7142-7142
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