TRANSCRIPTIONAL REPRESSION MEDIATED BY THE WT1 WILMS-TUMOR GENE-PRODUCT

被引:492
作者
MADDEN, SL
COOK, DM
MORRIS, JF
GASHLER, A
SUKHATME, VP
RAUSCHER, FJ
机构
[1] WISTAR INST, 3601 SPRUCE ST, PHILADELPHIA, PA 19104 USA
[2] HOWARD HUGHES MED INST, DEPT MED MOLEC GENET & CELL BIOL, CHICAGO, IL 60637 USA
关键词
D O I
10.1126/science.1654597
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The wt1 gene, a putative tumor suppressor gene located at the Wilms tumor (WT) locus on chromosome 11p13, encodes a zinc finger-containing protein that binds to the same DNA sequence as EGR-1, a mitogen-inducible immediate-early gene product that activates transcription. The transcriptional regulatory potential of WT1 has not been demonstrated. In transient transfection assays, the WT1 protein functioned as a repressor of transcription when bound to the EGR-1 site. The repression function was mapped to the glutamine- and proline-rich NH2-terminus of WT1; fusion of this domain to the zinc finger region of EGR-1 converted EGR-1 into a transcriptional repressor.
引用
收藏
页码:1550 / 1553
页数:4
相关论文
共 31 条
  • [1] ANDERSSON S, 1989, J BIOL CHEM, V264, P8222
  • [2] ISOLATION, CHARACTERIZATION, AND EXPRESSION OF THE MURINE WILMS-TUMOR GENE (WT1) DURING KIDNEY DEVELOPMENT
    BUCKLER, AJ
    PELLETIER, J
    HABER, DA
    GLASER, T
    HOUSMAN, DE
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (03) : 1707 - 1712
  • [3] ISOLATION AND CHARACTERIZATION OF A ZINC FINGER POLYPEPTIDE GENE AT THE HUMAN CHROMOSOME-11 WILMS TUMOR LOCUS
    CALL, KM
    GLASER, T
    ITO, CY
    BUCKLER, AJ
    PELLETIER, J
    HABER, DA
    ROSE, EA
    KRAL, A
    YEGER, H
    LEWIS, WH
    JONES, C
    HOUSMAN, DE
    [J]. CELL, 1990, 60 (03) : 509 - 520
  • [4] COOK DM, UNPUB
  • [5] ANALYSIS OF SP1 INVIVO REVEALS MULTIPLE TRANSCRIPTIONAL DOMAINS, INCLUDING A NOVEL GLUTAMINE-RICH ACTIVATION MOTIF
    COUREY, AJ
    TJIAN, R
    [J]. CELL, 1988, 55 (05) : 887 - 898
  • [6] COWELL JK, 1991, ONCOGENE, V6, P595
  • [7] PRESENCE OF A POTENT TRANSCRIPTION ACTIVATING SEQUENCE IN THE P53 PROTEIN
    FIELDS, S
    JANG, SK
    [J]. SCIENCE, 1990, 249 (4972) : 1046 - 1049
  • [8] HOMOZYGOUS DELETION IN WILMS-TUMORS OF A ZINC-FINGER GENE IDENTIFIED BY CHROMOSOME JUMPING
    GESSLER, M
    POUSTKA, A
    CAVENEE, W
    NEVE, RL
    ORKIN, SH
    BRUNS, GAP
    [J]. NATURE, 1990, 343 (6260) : 774 - 778
  • [9] TRANSCRIPTIONAL ACTIVATION AND REPRESSION BY FOS ARE INDEPENDENT FUNCTIONS - THE C-TERMINUS REPRESSES IMMEDIATE-EARLY GENE-EXPRESSION VIA CARG ELEMENTS
    GIUS, D
    CAO, XM
    RAUSCHER, FJ
    COHEN, DR
    CURRAN, T
    SUKHATME, VP
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (08) : 4243 - 4255
  • [10] RECOMBINANT GENOMES WHICH EXPRESS CHLORAMPHENICOL ACETYLTRANSFERASE IN MAMMALIAN-CELLS
    GORMAN, CM
    MOFFAT, LF
    HOWARD, BH
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (09) : 1044 - 1051