SEGREGATION OF MHC CLASS-II MOLECULES FROM MHC CLASS-I MOLECULES IN THE GOLGI-COMPLEX FOR TRANSPORT TO LYSOSOMAL COMPARTMENTS

被引：624

作者：

PETERS, PJ ^{[1
]}

NEEFJES, JJ ^{[1
]}

OORSCHOT, V ^{[1
]}

PLOEGH, HL ^{[1
]}

GEUZE, HJ ^{[1
]}

机构：

[1] NETHERLANDS CANC INST, DEPT CELLULAR BIOCHEM, 1066 CX AMSTERDAM, NETHERLANDS

来源：

NATURE | 1991年 / 349卷 / 6311期

关键词：

D O I：

10.1038/349669a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Traffic of MHC molecules dictates the source of peptides that are presented to T cells. The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively. In human B lymphoblastoid cells, class I molecules are present in compartments constituting the biosynthetic pathway, whereas class II molecules enter structures related to lysosomes during their biosynthesis.

引用

页码：669 / 676

页数：8

共 51 条

[1] PREDOMINANCE OF CLATHRIN LIGHT CHAIN LCB CORRELATES WITH THE PRESENCE OF A REGULATED SECRETORY PATHWAY [J].

ACTON, SL ;

BRODSKY, FM .

JOURNAL OF CELL BIOLOGY, 1990, 111 (04) :1419-1426

[2] INHIBITION BY BREFELDIN-A OF PRESENTATION OF EXOGENOUS PROTEIN ANTIGENS TO MHC CLASS-II-RESTRICTED T-CELLS [J].

ADORINI, L ;

ULLRICH, SJ ;

APPELLA, E ;

FUCHS, S .

NATURE, 1990, 346 (6279) :63-66

[3] VISUALIZATION OF ACIDIC ORGANELLES IN INTACT-CELLS BY ELECTRON-MICROSCOPY [J].

ANDERSON, RGW ;

FALCK, JR ;

GOLDSTEIN, JL ;

BROWN, MS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (15) :4838-4842

[4] MHC CLASS-II-ASSOCIATED INVARIANT CHAIN CONTAINS A SORTING SIGNAL FOR ENDOSOMAL COMPARTMENTS [J].

BAKKE, O ;

DOBBERSTEIN, B .

CELL, 1990, 63 (04) :707-716

[5] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].

BJORKMAN, PJ ;

SAPER, MA ;

SAMRAOUI, B ;

BENNETT, WS ;

STROMINGER, JL ;

WILEY, DC .

NATURE, 1987, 329 (6139) :506-512

[6] THE INTRACELLULAR TRAFFIC OF IMMUNOLOGICALLY ACTIVE MOLECULES [J].

BRODSKY, FM .

IMMUNOLOGY TODAY, 1984, 5 (12) :350-357

[7] THE BIOCHEMISTRY AND CELL BIOLOGY OF ANTIGEN PROCESSING [J].

CHAIN, BM ;

KAYE, PM ;

SHAW, MA .

IMMUNOLOGICAL REVIEWS, 1988, 106 :33-58

[8]

CRESSWELL P, 1987, CRIT REV IMMUNOL, V7, P31

[9]

DARNELL J, 1990, MOL CELL BIOL, P596

[10]

DAVIS JE, 1990, J IMMUNOL, V144, P990

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