TISSUE-TYPE PLASMINOGEN-ACTIVATOR (TPA) IS THE MAIN PLASMINOGEN-ACTIVATOR ASSOCIATED WITH ISOLATED RAT NERVE GROWTH CONES

被引：22
作者：
GARCIAROCHA, M
AVILA, J
ARMASPORTELA, R
机构：
[1] Centro de Biologia Molecular 'Severo Ochoa', CSIC-UAM, Facultad de Ciencias
来源：
NEUROSCIENCE LETTERS | 1994年 / 180卷 / 02期
关键词：
NERVE GROWTH CONE; PLASMINOGEN ACTIVATOR; NEURITE GROWTH;
D O I：
10.1016/0304-3940(94)90502-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Different studies in tissue culture have shown the involvement of plasminogen activators (PAs) in nerve growth-cone migration. We have studied PA activity associated with isolated rat brain growth cones. Fibrin-agarose zymographies show that tissue-type PA (tPA) is the main PA associated with these structures. After fractionation of growth cones, a slightly higher tPA activity was found associated with the particulate fraction. The present findings support the requirement of this protease for neurite growth.
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页码：123 / 126
页数：4
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