COMPARATIVE MUTAGENICITY OF 2-METHYLPROPENE (ISOBUTENE), ITS EPOXIDE 2-METHYL-1,2-EPOXYPROPANE AND PROPYLENE-OXIDE IN THE IN-VITRO MICRONUCLEUS TEST USING HUMAN-LYMPHOCYTES

被引：10

作者：

JORRITSMA, U

CORNET, M

VANHUMMELEN, P

BOLT, HM

VERCRUYSSE, A

KIRSCHVOLDERS, M

ROGIERS, V

机构：

[1] UNIV DORTMUND,INST ARBEITSPHYSIOL,TOXIKOL & ARBEITSMED ABT,D-44139 DORTMUND,GERMANY

[2] FREE UNIV BRUSSELS,DEPT TOXICOL,B-1090 BRUSSELS,BELGIUM

[3] FREE UNIV BRUSSELS,ANTROPOGENET LAB,B-1050 BRUSSELS,BELGIUM

来源：

MUTAGENESIS | 1995年 / 10卷 / 02期

关键词：

D O I：

10.1093/mutage/10.2.101

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

2-Methylpropene (isobutene), a gaseous compound widely used in chemical industries, is metabolized to the epoxide 2-methyl-1,2-epoxypropane. The parent compound has previously been shown to be non-mutagenic in a modified Ames test, whereas the epoxide metabolite gave a positive result, In this study, both compounds have been tested in the in vitro micronucleus test using human lymphocytes. Propylene oxide, a well known mutagenic compound, served as a positive control. It was found that 2-methylpropene had no mutagenic effect, whereas its epoxide induced a statistically significant dose-dependent increase in the number of micronuclei, The effect observed was comparable with that obtained for propylene oxide.

引用

页码：101 / 104

页数：4