SYNTHESIS AND TRANSFORMATIONS OF THE 20-SUBSTITUTED DERIVATIVES OF 16-ALPHA, 17-ALPHA-EPOXY-5-ALPHA-PREGNANE-3-BETA,21-DIOL-20-ONES

被引：2

作者：

TURUTA, AM

KAMERNITSKII, AV

DZHLANTIASHVILI, NV

KAVTARADZE, LK

KOROBOV, AA

机构：

[1] N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow

来源：

BULLETIN OF THE ACADEMY OF SCIENCES OF THE USSR DIVISION OF CHEMICAL SCIENCE | 1991年 / 40卷 / 05期

关键词：

D O I：

10.1007/BF00961375

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new and more effective sequence of reactions is proposed for the production of 16-alpha,17-alpha-isopropylidenedioxy-5-alpha-pregnane-3-beta,21-diol-20-one. It uses methods previously unused for 5-alpha-H-steroids and involves 21-hydroxylation of 16-alpha,17-alpha-epoxy-5-alpha-pregnan-3-beta-ol-20-one with diacetoxyiodobenzene and cis-opening of the obtained 21-hydroxy-16-alpha,17-alpha-epoxy-5-alpha-pregnane-3-beta,21-diol-20-one by acetic acid in the presence of epoxycarbonylhydrazine, followed by condensation of the obtained product with acetone.

引用

页码：1063 / 1065

页数：3