DETERMINATION OF IVERMECTIN RESIDUES IN SWINE TISSUES - AN IMPROVED CLEANUP PROCEDURE USING SOLID-PHASE EXTRACTION

被引：33
作者：
NORDLANDER, I
JOHNSSON, H
机构：
[1] Nutrition Laboratory, National Food Administration, Uppsala, S-751 26
来源：
FOOD ADDITIVES AND CONTAMINANTS | 1990年 / 7卷 / 01期
关键词：
HPLC-fluorescence detection; Ivermectin; Swine muscle tissue;
D O I：
10.1080/02652039009373823
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A rapid and sensitive HPLC method has been developed for the determination of ivermectin in swine tissues. The clean-up procedure is based on solid-phase extraction on a Bond-Elut C8 cartridge. The average recovery from spiked swine muscle tissue was 87% in the concentration range 2-20 μg/kg. The method has a limit of detection of 0.5-1 μg/kg. A survey of the levels in muscle tissues from 35 sanitary slaughtered sows was made. Five samples were found to contain ivermectin at concentrations between 3.4 and 27.6 μg/kg. A good correlation (r = 0.9696) was found between these results and those obtained using another established method. © 1990 Taylor & Francis Group, LLC.
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页码：79 / 82
页数：4
相关论文
共 5 条
  • [1] Campbell W.C., Fisher M.H., Stapley E.O., Albers-Schoberg G., Jacob T.A., Ivermectin: A potent new antiparasitic agent, Science, 221, pp. 823-828, (1983)
  • [2] Chiu S.H.L., Buhs R.P., Sestokas E., Taub R., Jacob T.A., Determination of ivermectin residue in animal tissues by high-performance liquid chromatography reverse isotope dilution assay, Journal of Agricultural and Food Chemistry, 33, pp. 99-102, (1985)
  • [3] Chiu S.H.L., Sestokas E., Taub R., Buhs R.P., Green M., Setokas R., Vandenheuvel W.J.A., Arisoin B.H., Jacob T.A., Metabolic disposition of ivermectin in tissues of cattle, sheep and rats, Drug Metabolism and Disposition. the American Society for Pharmacology and Experimental Therapeutics, 14, pp. 590-599, (1986)
  • [4] Slanina P., Kuivinen J., Ohlsen C., Ekstrom L.-G., Ivermectin residues in the edible tissues of swine and cattle: Effect of cooking and toxicological evaluation, Food Additives and Contaminants, 6, pp. 475-481, (1989)
  • [5] Tway P.C., Wood J.S., Downing G.V., Determination of ivermectin in cattle and sheep tissues using high-performance liquid chromatography with fluorescence detection, Journal of Agricultural and Food Chemistry, 29, pp. 1059-1063, (1981)
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