SYNTHESIS OF 4 STEREOISOMERS OF CARBOCYCLIC 5'-NOR D4A AND EVALUATION OF THEIR TRIPHOSPHATES AS SUBSTRATES FOR DNA-POLYMERASES

被引：21

作者：

DYATKINA, N

SEMIZAROV, D

VICTOROVA, L

KRAYEVSKY, A

THEIL, F

VONJANTALIPINSKI, M

机构：

[1] CTR SELECT ORGAN SYNTH,D-12484 BERLIN,GERMANY

[2] MAX DELBRUCK CTR MOLEC MED,D-13125 BERLIN,GERMANY

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012458

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A method was developed for synthesis of the four stereoisomeric enantiomerically pure 5'-nor carbocyclic nucleosides 4b, ent-4b, 10 and ent-10 starting from the common enantiomerically pure allylic monoacetate 1. Nucleoside analogues were converted to the corresponding triphosphate derivatives 6, ent-6, 12, and ent-12. The substrate properties of the latters towards different DNA polymerases were evaluated.

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页码：723 / 726

页数：4

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