LOW-GRADE LYMPHOMA - CLINICAL AND PROGNOSTIC STUDIES IN A SERIES OF 143 PATIENTS FROM A SINGLE INSTITUTION

被引：20

作者：

LOPEZGUILLERMO, A ^{[1
]}

MONTSERRAT, E ^{[1
]}

BOSCH, F ^{[1
]}

ESCODA, L ^{[1
]}

TEROL, MJ ^{[1
]}

MARIN, P ^{[1
]}

REVERTER, JC ^{[1
]}

BLADE, J ^{[1
]}

CERVANTES, F ^{[1
]}

SIERRA, J ^{[1
]}

NOMDEDEU, B ^{[1
]}

URBANOISPIZUA, A ^{[1
]}

ROUIRA, M ^{[1
]}

CARRERAS, E ^{[1
]}

CAMPO, E ^{[1
]}

ROZMAN, C ^{[1
]}

机构：

[1] UNIV BARCELONA,HOSP CLIN,POSTGRAD SCH HEMATOL FARRERAS VALENTI,E-08036 BARCELONA,SPAIN

来源：

LEUKEMIA & LYMPHOMA | 1994年 / 15卷 / 1-2期

关键词：

LOW GRADE LYMPHOMA; PROGNOSIS;

D O I：

10.3109/10428199409051692

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clinical and prognostic studies were carried out in a series of 143 patients with low-grade (small-lymphocytic, follicular small cleaved cell, follicular mixed small- and large-cell) lymphoma. After treatment with alkylating agents (21.5% cases), combination chemotherapy (73.3%) or other therapies (5.2%), complete response (CR) was obtained in 40.7% of cases and partial response (PR) in 43.7%. The stage of the disease was the most important factor for response. With a median follow-up of 6.5 years, 48.0% (95% Cl: 37.5-58.5) of patients were alive 10 years after diagnosis. Among the initial parameters, advanced stage, B-symptoms, poor performance status, nodal involvement >3 sites, extranodal involvement greater than or equal to 2 sites, WBC count greater than or equal to 10 x 10(9)/L, leukemic expression, high serum LDH levels, and bone marrow infiltration were all related to survival; treatment modality, however, had no influence on survival. In the multivariate analysis, stage (p = 0.008) and age (p = 0.053) were the most important prognostic factors. When considering response to therapy, both CR (p < 0.001) and PR (p = 0.003) emerged as the most important predictive variables, with only the absence of B-symptoms retaining its prognostic significance (p = 0.014) among the other parameters. In addition, in CR patients the duration of the response (less than or equal to 1 year vs. >1 year) was the most significant parameter for survival (p < 0.001). Finally, the initial stage (p = 0.011) and the hsitologic subtype (those patients with follicular mixed lymphoma relapsing less frequently than the others) (p = 0.052) were the only significant factors for relapse.

引用

页码：159 / 165

页数：7

共 32 条

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