DIRECT FORMATION OF (HALOARYL)COPPER NUCLEOPHILES FROM HALOIODOBENZENES AND ACTIVE COPPER

被引：11
作者：
EBERT, GW
PFENNIG, DR
SUCHAN, SD
DONOVAN, TA
AOUAD, E
TEHRANI, SS
GUNNERSEN, JN
DONG, LM
机构：
[1] Department of Chemistry, State University of New York College, Buffalo, New York 14222, Buffalo
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 08期
关键词：
D O I：
10.1021/jo00113a013
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(o-Halophenyl)-; (m-halophenyl)-, and (p-halophenyl)copper reagents have been formed in moderate to high yields at room temperature from active copper and the corresponding haloiodobenzenes. These reagents have been cross-coupled with a variety of alkyl and acyl halides to produce the respective haloarenes and haloaryl ketones. Remarkably, (o-fluorophenyl)- and (o-chlorophenyl)copper are produced in good yields by this procedure without undergoing elimination to form benzyne making this approach a convenient method for generating o-halophenyl nucleophiles.
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页码：2361 / 2364
页数：4
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