ANTITUMOR ACTIVE POLYSACCHARIDES FROM THE CHINESE MUSHROOM SONGSHAN-LINGZHI, THE FRUITING BODY OF GANODERMA-TSUGAE

被引：91
作者：
WANG, GY
ZHANG, J
MIZUNO, T
ZHUANG, C
ITO, H
MAYUZUMI, H
OKAMOTO, H
LI, JX
机构：
[1] SHIZUOKA UNIV, FAC AGR, OYA, SHIZUOKA 422, JAPAN
[2] CHANGCHUN COLL TRAD CHINESE MED, DEPT TRADIT CHINESE PHARM, CHANGCHUN, PEOPLES R CHINA
[3] NIKKEI MUSHROOM DEV, HIGASHI, GUNMA 37932, JAPAN
[4] REISHI RES SOC, TAKAMATSU, KAGAWA 760, JAPAN
[5] JILIN PROVINCE BIOL INST, CHANGCHUN, PEOPLES R CHINA
[6] MIE UNIV, SCH MED, TSU, MIE 514, JAPAN
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1993年 / 57卷 / 06期
关键词：
D O I：
10.1271/bbb.57.894
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A systematic method of extraction, fractionation, and purification of polysaccharides from Songshan Lingzhi (Ganoderma tsugae) with antitumor activity was established. Seven glycans with strong antitumor activities were obtained from 14 water-soluble, and 15 water-insoluble fractions: FI(o)-a, FA-1, FII-1, FIII-2, and FIII-2-a, -b, and -c. FI(o)-a and FA-1 were protein-containing glucogalactans associated with mannose and fucose. FII-1 was a (1-->3)-beta-D-glucan having a lower protein content. The water-insoluble fractions FIII-2-a, -b, and -c were extracted with alkali, and were found to be protein-containing (1-->3)-beta-D-glucans showing the strongest activity. Chemical properties and structure of each antitumor polysaccharide were compared with three fungi of the Ganoderma family, Kofukitake (G. applanatum), Mannentake (G. lucidum), and Songshan Lingzhi (G. tsugae).
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页码：894 / 900
页数：7
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