EPSP SYNTHASE INHIBITOR DESIGN .2. THE IMPORTANCE OF THE 3-PHOSPHATE GROUP FOR LIGAND-BINDING AT THE SHIKIMATE-3-PHOSPHATE SITE AND THE IDENTIFICATION OF 3-MALONATE ETHERS AS NOVEL 3-PHOSPHATE MIMICS

被引：17

作者：

MILLER, MJ

ANDERSON, KS

BRACCOLINO, DS

CLEARY, DG

GRUYS, KJ

HAN, CY

LIN, KC

PANSEGRAU, PD

REAM, JE

SAMMONS, RD

SIKORSKI, JA

机构：

[1] MONSANTO CORP RES,UNIT MONSANTO CO,700 CHESTERFIELD PKWY N,ST LOUIS,MO 63198

[2] MONSANTO CORP RES,DIV NEW PROD,AGR GRP,ST LOUIS,MO 63198

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(01)80425-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Studies using alternate substrates, inhibitor product mimics and new derivatives of 4,5-dideoxy-shikimate-3-phosphate (ddS3P) are reported which indicate that the 3-phosphate group contributes significantly to substrate and inhibitor recognition at the shikimate 3-phosphate (S3P) site and that 3-malonate ethers will function as suitable 3-phosphate replacements for substrate and inhibitor binding to the S3P site of this enzyme.

引用

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页码：1435 / 1440

页数：6

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