REEXAMINATION OF THE CODING POTENTIAL OF THE HTLV-1 PX REGION

被引:13
作者
CAPUTO, A [1 ]
HASELTINE, WA [1 ]
机构
[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT HUMAN RETROVIROL,44 BINNEY ST,BOSTON,MA 02115
关键词
D O I
10.1016/0042-6822(92)90516-R
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T cell leukemia (ATL) and tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM). In addition to tax and rex genes eight additional open reading frames are present in the pX region of HTLV-1. The possibility that these open reading frames can encode a protein in human cell lines persistently infected by HTLV-1 or in COS-1 cells transfected with a pX expressor plasmid was investigated. The results presented here indicate that tax and rex are the only proteins detected. Moreover, antibodies against proteins in vitro translated by five of the additional open reading frames of the pX region were not found in sera of ATL and TSP/HAM patients, further indicating that those proteins are not usually made in infected cells. © 1992.
引用
收藏
页码:618 / 627
页数:10
相关论文
共 39 条
[1]  
BARTHOLOMEW C, 1986, LANCET, V2, P99
[2]   DETECTION OF HUMAN T-CELL LYMPHOMA LEUKEMIA-VIRUS TYPE-I DNA AND ANTIGEN IN SPINAL-FLUID AND BLOOD OF PATIENTS WITH CHRONIC PROGRESSIVE MYELOPATHY [J].
BHAGAVATI, S ;
EHRLICH, G ;
KULA, RW ;
KWOK, S ;
SNINSKY, J ;
UDANI, V ;
POIESZ, BJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1988, 318 (18) :1141-1147
[3]   IDENTIFICATION OF A PROTEIN ENCODED BY THE VPU GENE OF HIV-1 [J].
COHEN, EA ;
TERWILLIGER, EF ;
SODROSKI, JG ;
HASELTINE, WA .
NATURE, 1988, 334 (6182) :532-534
[4]  
CULLEN BR, 1987, METHOD ENZYMOL, V152, P684
[5]  
DOKHELAR MC, 1989, J ACQ IMMUN DEF SYND, V2, P431
[6]   MULTIPLE ALIGNED SEQUENCE EDITOR (MASE) [J].
FAULKNER, DV ;
JURKA, J .
TRENDS IN BIOCHEMICAL SCIENCES, 1988, 13 (08) :321-322
[7]   HUMAN T-CELL LEUKEMIA-VIRUS (HTLV-I) TRANSCRIPTS IN FRESH AND CULTURED-CELLS OF PATIENTS WITH ADULT T-CELL LEUKEMIA [J].
FRANCHINI, G ;
WONGSTAAL, F ;
GALLO, RC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (19) :6207-6211
[8]  
GAZDAR AF, 1980, BLOOD, V55, P409
[9]   HUMAN T-CELL LEUKEMIA-LYMPHOMA VIRUS TYPE-I (HTLV-I) EXPRESSION IN FRESH PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM PATIENTS WITH TROPICAL SPASTIC PARAPARESIS HTLV-I-ASSOCIATED MYELOPATHY [J].
GESSAIN, A ;
LOUIE, A ;
GOUT, O ;
GALLO, RC ;
FRANCHINI, G .
JOURNAL OF VIROLOGY, 1991, 65 (03) :1628-1633
[10]   SV40-TRANSFORMED SIMIAN CELLS SUPPORT THE REPLICATION OF EARLY SV40 MUTANTS [J].
GLUZMAN, Y .
CELL, 1981, 23 (01) :175-182