A LOCUS-CONTROL REGION IN THE T-CELL RECEPTOR ALPHA/DELTA LOCUS

被引：94

作者：

DIAZ, P ^{[1
]}

CADO, D ^{[1
]}

WINOTO, A ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY, CANC RES LAB, BERKELEY, CA 94720 USA

来源：

IMMUNITY | 1994年 / 1卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/1074-7613(94)90099-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A locus control region (LCR) is a set of cis-acting elements that regulate chromatin accessibility of a gene locus. In the T cell receptor (TCR) alpha/delta locus, an LCR might regulate the differential tissue and developmental expression and the rearrangement of TCR alpha and delta genes. We have localized a region 3' of the TCR alpha/delta locus containing eight T cell-specific nuclease hypersensitive domains (HS-1 to HS-8), which fit the characteristics of an LCR. In transgenic mice, a TCR alpha gene linked to this region is expressed at a high level, independent of the site of integration and correlates with gene copy number. The transgene is expressed in the alpha beta but not the gamma delta T cell subset and is activated at the right time during development. Proper LCR function requires the region containing HS-2 to HS-6. We propose a model of LCR competition to explain the differential regulation of TCR alpha versus delta genes during development.

引用

页码：207 / 217

页数：11

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