LINKAGE ANALYSIS OF FAMILIES WITH SEVERE CHILDHOOD AUTOSOMAL RECESSIVE MUSCULAR-DYSTROPHY IN MOROCCO INDICATES GENETIC HOMOGENEITY OF THE DISEASE IN NORTH-AFRICA

被引：29

作者：

ELKERCH, F

SEFIANI, A

AZIBI, K

BOUTALEB, N

YAHYAOUI, M

BENTAHILA, A

VINET, MC

LETURCQ, F

BACHNER, L

BECKMANN, J

CAMPBELL, KP

TOME, FMS

FARDEAU, M

KAPLAN, JC

机构：

[1] INST COCHIN GENET MOLEC, INSERM, U129, F-75014 PARIS, FRANCE

[2] INH, DEPT MOLEC BIOL & GENET, RABAT, MOROCCO

[3] HOP SPECIAL, SERV NEUROL, RABAT, MOROCCO

[4] HOP ENFANTS, SERV PEDIAT, RABAT, MOROCCO

[5] CHU ALGER OUSET, HOP BOLOGHINE, ALGIERS, ALGERIA

[6] CTR ETUD POLYMORPHISME HUMAIN, F-75010 PARIS, FRANCE

[7] UNIV IOWA, COLL MED, HOWARD HUGHES MED INST, IOWA CITY, IA 52242 USA

[8] INSERM, U153, PARIS, FRANCE

[9] CNRS, URA 614, PARIS, FRANCE

来源：

JOURNAL OF MEDICAL GENETICS | 1994年 / 31卷 / 04期

关键词：

D O I：

10.1136/jmg.31.4.342

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

It has been previously shown in Tunisian and Algerian families that the locus for SCARMD maps to the proximal part of 13q, and in Algerian families that the disease is associated with deficiency of the 50 kDa dystrophin associated glycoprotein (50DAG). We have tested this linkage in six families from Morocco where this disease is also prevalent. In one family the 50DAG was tested and found to be negative in a muscle biopsy. Our results showed similar linkage in this country, with statistical tests indicating genetic homogeneity between the three Maghreb countries.

引用

页码：342 / 343

页数：2

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