Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer

被引：240

作者：

Kohno, Takashi ^{[1
,2
,3
,4
]}

Nakaoku, Takashi ^{[1
]}

Tsuta, Koji ^{[5
]}

Tsuchihara, Katsuya ^{[2
]}

Matsumoto, Shingo ^{[2
,3
,4
]}

Yoh, Kiyotaka ^{[3
,4
]}

Goto, Koichi ^{[3
,4
]}

机构：

[1] Natl Canc Ctr, Res Inst, Div Genome Biol, Tokyo, Japan

[2] Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr EPOC, Div Translat Res, Tokyo, Japan

[3] Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr EPOC, Div Translat Res, Chiba, Japan

[4] Natl Canc Ctr Hosp East, Div Thorac Oncol, Chiba, Japan

[5] Natl Canc Ctr, Div Pathol & Clin Labs, Tokyo, Japan

来源：

TRANSLATIONAL LUNG CANCER RESEARCH | 2015年 / 4卷 / 02期

关键词：

RET fusion; ROS1; fusion; oncogene fusion; tyrosine kinase inhibitor (TKI); multiplex diagnosis system;

D O I：

10.3978/j.issn.2218-6751.2014.11.11

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fusions of the RET and ROS1 protein tyrosine kinase oncogenes with several partner genes were recently identified as new targetable genetic aberrations in cases of non-small cell lung cancer (NSCLC) lacking activating EGFR, KRAS, ALK, BRAF, or HER2 oncogene aberrations. RET and ROS1 fusion-positive tumors are mainly observed in young, female, and/or never smoking patients. Studies based on in vitro and in vivo (i.e., mouse) models and studies of several fusion-positive patients indicate that inhibiting the kinase activity of the RET and ROS1 fusion proteins is a promising therapeutic strategy. Accordingly, there are several ongoing clinical trials aimed at examining the efficacy of tyrosine kinase inhibitors (TKIs) against RET and ROS1 proteins in patients with fusion-positive lung cancer. Other gene fusions (NTRK1, NRG1, and FGFR1/2/3) that are targetable by existing TKIs have also been identified in NSCLCs. Options for personalized lung cancer therapy will be increased with the help of multiplex diagnosis systems able to detect multiple druggable gene fusions.

引用

页码：156 / 164

页数：9

共 53 条

[1] Mouse Model for ROS1-Rearranged Lung Cancer [J].

Arai, Yasuhito ;

Totoki, Yasushi ;

Takahashi, Hiroyuki ;

Nakamura, Hiromi ;

Hama, Natsuko ;

Kohno, Takashi ;

Tsuta, Koji ;

Yoshida, Akihiko ;

Asamura, Hisao ;

Mutoh, Michihiro ;

Hosoda, Fumie ;

Tsuda, Hitoshi ;

Shibata, Tatsuhiro .

PLOS ONE, 2013, 8 (02)

[2] ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers [J].

Bergethon, Kristin ;

Shaw, Alice T. ;

Ou, Sai-Hong Ignatius ;

Katayama, Ryohei ;

Lovly, Christine M. ;

McDonald, Nerina T. ;

Massion, Pierre P. ;

Siwak-Tapp, Christina ;

Gonzalez, Adriana ;

Fang, Rong ;

Mark, Eugene J. ;

Batten, Julie M. ;

Chen, Haiquan ;

Wilner, Keith D. ;

Kwak, Eunice L. ;

Clark, Jeffrey W. ;

Carbone, David P. ;

Ji, Hongbin ;

Engelman, Jeffrey A. ;

Mino-Kenudson, Mari ;

Pao, William ;

Iafrate, A. John .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (08) :863-870

[3] Complete metabolic response in a patient with repeatedly relapsed non-small cell lung cancer harboring ROSI gene rearrangement after treatment with crizotinib [J].

Bos, M. ;

Gardizi, M. ;

Schildhaus, H. U. ;

Heukamp, L. C. ;

Geist, T. ;

Kaminsky, B. ;

Zander, T. ;

Nogova, L. ;

Scheffler, M. ;

Dietlein, M. ;

Kobe, C. ;

Holstein, A. ;

Maintz, D. ;

Buettner, R. ;

Wolf, J. .

LUNG CANCER, 2013, 81 (01) :142-143

[4] Clinical and the Prognostic Characteristics of Lung Adenocarcinoma Patients with ROS1 Fusion in Comparison with Other Driver Mutations in East Asian Populations [J].

Chen, Yen-Fu ;

Hsieh, Min-Shu ;

Wu, Shang-Gin ;

Chang, Yih-Leong ;

Shih, Jin-Yuan ;

Liu, Yi-Nan ;

Tsai, Meng-Feng ;

Tsai, Tzu-Hsiu ;

Yu, Chong-Jen ;

Yang, James Chih-Hsin ;

Yang, Pan-Chyr .

JOURNAL OF THORACIC ONCOLOGY, 2014, 9 (08) :1171-1179

[5] Dramatic Response to Crizotinib in ROS1 Fluorescent In Situ Hybridization- and Immunohistochemistry-Positive Lung Adenocarcinoma: A Case Series [J].

Chiari, Rita ;

Buttitta, Fiamma ;

Iacono, Daniela ;

Bennati, Chiara ;

Metro, Giulio ;

Di Lorito, Alessia ;

Iezzi, Manuela ;

Tiseo, Marcello ;

Mazzoni, Francesca ;

Cappuzzo, Federico ;

Marchetti, Antonio ;

Crino, Lucio .

CLINICAL LUNG CANCER, 2014, 15 (06) :470-474

[6] The quest to overcome resistance to EGFR-targeted therapies in cancer [J].

Chong, Curtis R. ;

Jaenne, Pasi A. .

NATURE MEDICINE, 2013, 19 (11) :1389-1400

[7] Comprehensive molecular profiling of lung adenocarcinoma [J].

Collisson, Eric A. ;

Campbell, Joshua D. ;

Brooks, Angela N. ;

Berger, Alice H. ;

Lee, William ;

Chmielecki, Juliann ;

Beer, David G. ;

Cope, Leslie ;

Creighton, Chad J. ;

Danilova, Ludmila ;

Ding, Li ;

Getz, Gad ;

Hammerman, Peter S. ;

Hayes, D. Neil ;

Hernandez, Bryan ;

Herman, James G. ;

Heymach, John V. ;

Jurisica, Igor ;

Kucherlapati, Raju ;

Kwiatkowski, David ;

Ladanyi, Marc ;

Robertson, Gordon ;

Schultz, Nikolaus ;

Shen, Ronglai ;

Sinha, Rileen ;

Sougnez, Carrie ;

Tsao, Ming-Sound ;

Travis, William D. ;

Weinstein, John N. ;

Wigle, Dennis A. ;

Wilkerson, Matthew D. ;

Chu, Andy ;

Cherniack, Andrew D. ;

Hadjipanayis, Angela ;

Rosenberg, Mara ;

Weisenberger, Daniel J. ;

Laird, Peter W. ;

Radenbaugh, Amie ;

Ma, Singer ;

Stuart, Joshua M. ;

Byers, Lauren Averett ;

Baylin, Stephen B. ;

Govindan, Ramaswamy ;

Meyerson, Matthew ;

Rosenberg, Mara ;

Gabriel, Stacey B. ;

Cibulskis, Kristian ;

Sougnez, Carrie ;

Kim, Jaegil ;

Stewart, Chip .

NATURE, 2014, 511 (7511) :543-550

[8] Molecular Analysis for Therapy Choice: NCI MATCHd [J].

Conley, Barbara A. ;

Doroshow, James H. .

SEMINARS IN ONCOLOGY, 2014, 41 (03) :297-299

[9] Molecular Pathways: ROS1 Fusion Proteins in Cancer [J].

Davies, Kurtis D. ;

Doebele, Robert C. .

CLINICAL CANCER RESEARCH, 2013, 19 (15) :4040-4045

[10] Identifying and Targeting ROS1 Gene Fusions in Non-Small Cell Lung Cancer [J].

Davies, Kurtis D. ;

Le, Anh T. ;

Theodoro, Mariana F. ;

Skokan, Margaret C. ;

Aisner, Dara L. ;

Berge, Eamon M. ;

Terracciano, Luigi M. ;

Cappuzzo, Federico ;

Incarbone, Matteo ;

Roncalli, Massimo ;

Alloisio, Marco ;

Santoro, Armando ;

Camidge, D. Ross ;

Varella-Garcia, Marileila ;

Doebele, Robert C. .

CLINICAL CANCER RESEARCH, 2012, 18 (17) :4570-4579

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