RECOGNITION OF COMPLEX OLIGOSACCHARIDES BY THE MULTISUBUNIT ASIALOGLYCOPROTEIN RECEPTOR

被引：113

作者：

LODISH, HF ^{[1
]}

机构：

[1] MIT, DEPT BIOL, CAMBRIDGE, MA 02142 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 10期

关键词：

D O I：

10.1016/0968-0004(91)90154-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hepatic asialoglycoprotein receptor, a galactose lectin, is an oligomer of two types of similar polypeptide chains, each of which weakly binds galactose. High-affinity binding of complex oligosaccharides requires a precise geometric arrangement of receptor subunits. The two subunits have different functions in receptor assembly, ligand binding and endocytosis.

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页码：374 / 377

页数：4

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