The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity

被引：41

作者：

Hasan, Noviany ^{[1
,2
]}

Osman, Hasnah ^{[1
]}

Mohamad, Suriyati ^{[3
]}

Chong, Wong Keng ^{[1
]}

Awang, Khalijah ^{[4
]}

Zahariluddin, Anis Safirah Mohd ^{[3
]}

机构：

[1] Univ Sci Malaysia, Sch Chem Sci, Minden 11800, Penang, Malaysia

[2] Univ Lampung, Dept Chem, Bandar Lampung 35145, Lampung, Indonesia

[3] Univ Sci Malaysia, Sch Biol Sci, Minden 11800, Penang, Malaysia

[4] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 50603, Malaysia

来源：

PHARMACEUTICALS | 2012年 / 5卷 / 08期

关键词：

isovestitol; medicarpin; sativan; betulinic acid; Sesbania grandiflora; antituberculosis activity; Mycobacterium tuberculosis;

D O I：

10.3390/ph5080882

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, H-1- and C-13-NMR, DEPT, COSY, BMOC, HMBC, and MS analysis). All the tested compounds 1-4 exhibited antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 mu g/mL for compounds 1-3, and 100 mu g/mL for compound 4, whereas, the methanol extract exhibited antituberculosis activity of 625 mu g/mL. This is the first report on the occurrence of isoflavonoids in this plant and their antituberculosis activity.

引用

页码：882 / 889

页数：8

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