CELLULAR PHARMACOLOGY OF 2',3'-DIDEOXY-2',3'-DIDEHYDROTHYMIDINE, A NUCLEOSIDE ANALOG ACTIVE AGAINST HUMAN IMMUNODEFICIENCY VIRUS

被引：181
作者：
HO, HT [1 ]
HITCHCOCK, MJM [1 ]
机构：
[1] BRISTOL MYERS CO,DIV PHARMACEUT RES & DEV,POB 5100,5 RES PKWY,WALLINGFORD,CT 06492
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1989年 / 33卷 / 06期
关键词：
D O I：
10.1128/AAC.33.6.844
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
引用
收藏
页码：844 / 849
页数：6
相关论文
共 27 条
[1]   INITIAL STUDIES ON THE CELLULAR PHARMACOLOGY OF 3'-DEOXYTHYMIDIN-2'-ENE (D4T) - A POTENT AND SELECTIVE INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS [J].
AUGUST, EM ;
MARONGIU, ME ;
LIN, TS ;
PRUSOFF, WH .
BIOCHEMICAL PHARMACOLOGY, 1988, 37 (23) :4419-4422
[2]   BOTH 2',3'-DIDEOXYTHYMIDINE AND ITS 2',3'-UNSATURATED DERIVATIVE (2',3'-DI-DEOXYTHYMIDINENE) ARE POTENT AND SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-REPLICATION INVITRO [J].
BABA, M ;
PAUWELS, R ;
HERDEWIJN, P ;
DECLERCQ, E ;
DESMYTER, J ;
VANDEPUTTE, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 142 (01) :128-134
[3]   THE INVITRO AND INVIVO ANTI-RETROVIRUS ACTIVITY, AND INTRACELLULAR METABOLISM OF 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE AND 2',3'-DIDEOXYCYTIDINE ARE HIGHLY DEPENDENT ON THE CELL SPECIES [J].
BALZARINI, J ;
PAUWELS, R ;
BABA, M ;
HERDEWIJN, P ;
DECLERCQ, E ;
BRODER, S ;
JOHNS, DG .
BIOCHEMICAL PHARMACOLOGY, 1988, 37 (05) :897-903
[4]  
BALZARINI J, 1987, MOL PHARMACOL, V32, P162
[5]   ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) [J].
BARRESINOUSSI, F ;
CHERMANN, JC ;
REY, F ;
NUGEYRE, MT ;
CHAMARET, S ;
GRUEST, J ;
DAUGUET, C ;
AXLERBLIN, C ;
VEZINETBRUN, F ;
ROUZIOUX, C ;
ROZENBAUM, W ;
MONTAGNIER, L .
SCIENCE, 1983, 220 (4599) :868-871
[6]   KINETIC AND PHOTOCHEMICAL STUDIES AND ALTERATION OF UV SENSITIVITY OF ESCHERICHIA-COLI THYMIDINE KINASE BY HALOGENATED ALLOSTERIC REGULATORS AND SUBSTRATE ANALOGS [J].
CHEN, MS ;
PRUSOFF, WH .
BIOCHEMISTRY, 1977, 16 (15) :3310-3315
[7]  
CHEN MS, 1978, J BIOL CHEM, V253, P1325
[8]   PROPERTIES OF 2',3'-DIDEOXY-2',3'-DEHYDROTHYMIDINE 5'-TRIPHOSPHATE IN TERMINATING DNA-SYNTHESIS CATALYZED BY SEVERAL DIFFERENT DNA-POLYMERASES [J].
DYATKINA, N ;
MINASSIAN, S ;
KUKHANOVA, M ;
KRAYEVSKY, A ;
VONJANTALIPINSKY, M ;
CHIDGEAVADZE, Z ;
BEABEALASHVILLI, R .
FEBS LETTERS, 1987, 219 (01) :151-155
[9]   THE EFFICACY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].
FISCHL, MA ;
RICHMAN, DD ;
GRIECO, MH ;
GOTTLIEB, MS ;
VOLBERDING, PA ;
LASKIN, OL ;
LEEDOM, JM ;
GROOPMAN, JE ;
MILDVAN, D ;
SCHOOLEY, RT ;
JACKSON, GG ;
DURACK, DT ;
KING, D .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) :185-191
[10]   EFFECTS OF 3'-AZIDO-3'-DEOXYTHYMIDINE ON THE DEOXYNUCLEOTIDE TRIPHOSPHATE POOLS OF CULTURED HUMAN-CELLS [J].
FRICK, LW ;
NELSON, DJ ;
STCLAIR, MH ;
FURMAN, PA ;
KRENITSKY, TA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 154 (01) :124-129
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