Evaluation of the Efficiency of Tc-99m-DMSA as a Radiopharmaceutical in Dynamic Renal Scans

被引:3
作者
Fahmy, Heba M. [1 ]
Yassin, Hossam M. [2 ]
Muhamed, Islam M. [1 ]
Mohamed, Samar E. [1 ]
Hassan, Shimaa S. [1 ]
机构
[1] Cairo Univ, Dept Biophys, Fac Sci, Cairo, Egypt
[2] Cairo Univ Hosp, Cairo, Egypt
关键词
Radiopharmaceutical; GFR; DMSA; DTPA; dynamic renal imaging; static renal imaging;
D O I
10.5152/etd.2018.0014
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: In dynamic renal scans, Tc-99m-diethylenetriamine pentaacetic acid (DTPA) is copiously used and it yields information about the renal blood-flow and the excretory capacity. Tc-99m-dimercaptosuccinic acid (DMSA) is used for static renal imaging and can likewise uncover the renal cortical structure. This work was intended to evaluate whether DMSA can be declared as a radiopharmaceutical in dynamic renal scans or not. It also aimed at comparing the outcomes procured from DMSA and with DTPA examinations. Materials and Methods: A comparison of the information gained from the renograms of 47 subjects (normal subjects and subjects with abnormal renal function having: obstructive nephropathy, bilateral nephropathy, hydronephrosis, reduced or non-function kidney, and/or atrophic kidney) who had Tc-99m-DMSA and Tc-99m-DTPA dynamic scintigraphies utilizing the same protocol. Results: A strong positive correlation had come in view on the evaluation of the left kidney, right kidney, and total glomerular filtration rate (GFR) from Tc-99m-DTPA and Tc-99m-DMSA renograms. In addition, the estimation of the time of the peak height from Tc-99m-DTPA and Tc-99m-DMSA renograms for the right and left kidneys demonstrated as non-significant varieties and a strong positive correlation for both the normal subjects and subjects with kidney abnormalities. Conclusion: In the light of the outcomes gained from the present investigation, it could be prescribed that Tc-99m-DMSA can favorably replace Tc-99m-DTPA in dynamic renograms in the case of the renal conditions that had been examined in the present work. As scheduled, this will be cost-effective and time saving and will decrease the radiation dose administered to the subjects. Also, the same qualities of results are accomplished with both radiopharmaceuticals in normal subjects and subjects with abnormal renal function.
引用
收藏
页码:140 / 147
页数:8
相关论文
共 49 条
  • [41] Insight into the Stability, Reactivity, Structural and Spectral Properties of the Anti, Syn-endo and Syn-exo Isomers of Bis(N-ethoxy-N-ethyl-dithiocarbamato)Nitrido Technetium-99m [Tc-99m-N(NOEt)(2)] Radiopharmaceutical
    Nabati, Mehdi
    CHEMICAL METHODOLOGIES, 2018, 2 (03): : 223 - 238
  • [42] The value of different washout parameters in the evaluation of renal transplants by technetium-99m-ethylene-I-I-dicysteine
    Kanmaz, Bedii
    Sayman, Haluk B.
    Alan, Nalan
    Devranoglu, Gevher
    Nisli, Serap
    Sonmezoglu, Kerim
    Kabasakal, Levent
    Halac, Metin
    Onsel, Cetin
    Uslu, Ilhami
    HELLENIC JOURNAL OF NUCLEAR MEDICINE, 2010, 13 (02): : 127 - 131
  • [43] A prospective study evaluating impact on renal function following percutaneous nephrolithotomy using Tc99m ethylenedicysteine renal scan: Does multiplicity of access tracts play a role?
    Yadav, Ram
    Agarwal, Samarth
    Sankhwar, Satyanarayan
    Goel, Apul
    Kumar, Manoj
    Singh, Manmeet
    Aeron, Ruchir
    Kumar, Vikas
    INVESTIGATIVE AND CLINICAL UROLOGY, 2019, 60 (01) : 21 - 28
  • [44] Tc-99m diethylenetriamine pentaacetic acid (DTPA): Is it reliable for assessment of methotrexate-induced cumulative effect on renal filtration in rheumatoid arthritis patients?
    Amin, Amr
    Effat, Dina
    Goher, Nabila
    Ramadan, Basma
    EGYPTIAN RHEUMATOLOGIST, 2013, 35 (01) : 5 - 8
  • [45] Tc-99 m diethylenetriamine-pentaacetic acid (DTPA): is it reliable for assessment of methotrexate-induced cumulative effect on renal filtration in rheumatoid arthritis patients?
    Amr Amin
    Dina Effat
    Nabila Goher
    Basma Ramadan
    Rheumatology International, 2013, 33 : 3059 - 3063
  • [46] Tc-99 m diethylenetriamine-pentaacetic acid (DTPA): is it reliable for assessment of methotrexate-induced cumulative effect on renal filtration in rheumatoid arthritis patients?
    Amin, Amr
    Effat, Dina
    Goher, Nabila
    Ramadan, Basma
    RHEUMATOLOGY INTERNATIONAL, 2013, 33 (12) : 3059 - 3063
  • [47] A study on comparison of Tc-99m DTPA renal dynamic imaging with Mayo quadratic, Cockcroft-Gault, MDRD, and CKD-EPI formulas for estimation of glomerular filtration rate among South Indian live-related kidney donors
    Aralapuram, Kishan
    Shetty, Bhushan Chandrahasa
    Gurusiddaiah, Sreedhara Chikkanayakanahalli
    JOURNAL OF RENAL INJURY PREVENTION, 2024, 13 (04):
  • [48] New normal values not related to age and sex, of glomerular filtration rate by 99mTc-DTPA renal dynamic imaging, for the evaluation of living kidney graft donors
    Zhao, Xiuyi
    Shao, Yahui
    Wang, Yanming
    Tian, Jun
    Sun, Ben
    Ru, Yanhui
    Zhang, Aimin
    Hao, Junwen
    HELLENIC JOURNAL OF NUCLEAR MEDICINE, 2012, 15 (03): : 210 - 214
  • [49] Renal output efficiency and normalized residual activity examined by technetium-99m-DTPA renography have by far greater specificity to diagnose obstructive disease as compared to other conventional parameters of the renogram. First such study of output efficiency
    Beatovic, Slobodanka Lj
    Radulovic, Media
    Jankovic, Milica M.
    Artiko, Vera M.
    Ajdinovic, Boris
    Sobic-Saranovic, Dragana P.
    HELLENIC JOURNAL OF NUCLEAR MEDICINE, 2018, 21 (02): : 140 - 144