SYNTHESIS AND BIOLOGICAL-ACTIVITY OF PEPTIDE ANTAGONISTS OF LULIBERIN (LUTEINIZING-HORMONE-RELEASING HORMONE)

被引：19
作者：
MOERSCH, GW
REBSTOCK, MC
WITTLE, EL
TINNEY, FJ
NICOLAIDES, ED
HUTT, MP
MICH, TF
VANDENBELT, JM
EDGREN, RE
REEL, JR
DERMODY, WC
HUMPHREY, RR
机构：
[1] WARNER LAMBERT PARKE DAVIS,DIV PHARMACEUT RES,DEPT CHEM,ANN ARBOR,MI 48106
[2] WARNER LAMBERT PARKE DAVIS,DIV PHARMACEUT RES,DEPT PHARMACOL,ANN ARBOR,MI 48106
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 08期
关键词：
D O I：
10.1021/jm00194a010
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of des-His2octa-and nonapeptide analogues of luliberin (luteinizing hormone-releasing hormone) with modifications in the 1 and 6 positions, and in some instances the 10 position, has been prepared. Some of these analogues are potent inhibitors of luliberin in vitro and in vivo. The use of ultraviolet absorption measurements for evaluating peptides containing tyrosine and tryptophan is described. An efficient synthesis of O-methyl-D-tyrosine is reported. © 1979, American Chemical Society. All rights reserved.
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页码：935 / 943
页数：9
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