SUPPRESSION OF MALARIAL PARASITAEMIA BY PYRIMETHAMINE IN COMBINATION WITH DAPSONE OR SULPHORMETHOXINE

被引：77

作者：

LUCAS, AO

HENDRICKSE, RG

OKUBADEJO, OA

RICHARDS, WH

NEAL, RA

KOFIE, BAK

机构：

[1] Wellcome Laboratories of Tropical Medicine, Beckenham, Kent

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1969年 / 63卷 / 02期

关键词：

D O I：

10.1016/0035-9203(69)90150-3

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The antimalarial activity of pyrimethamine in combination either with dapsone or with sulphormethoxine, was compared with that of pyrimethamine alone. In this double-blind controlled study, 280 children, living in an area of stable P. falciparum malaria, were observed during one year. With pyrimethamine alone there was incomplete suppression of parasitaemia with crude parasite rates ranging from 2 to 25%. The first dose of the drug combinations produced a rapid clearance of parasitaemia, and weekly administration of the drug combinations sustained a virtually complete suppression of parasitaemia throughout the year. The drugs were well tolerated and no serious side-effects were encountered among the treated children. © 1969 Royal Society of Tropical Medicine and Hygiene.

引用

页码：216 / +

页数：1

共 19 条

[1]

Archibald H. M., 1960, West African Medical Journal NS, V9, P21

[2]

ARCHIBALD H M, 1960, J Trop Med Hyg, V63, P25

[3]

Bratton AC, 1939, J BIOL CHEM, V128, P537

[4] EVALUATION OF SULFONAMIDES ALONE OR IN COMBINATION WITH PYRIMETHAMINE IN TREATMENT OF MULTI-RESISTANT FALCIPARUM MALARIA [J].