DIFFERENTIAL EXPRESSION AND ACTIVATION OF A FAMILY OF MURINE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS

被引：1248

作者：

KLIEWER, SA ^{[1
]}

FORMAN, BM ^{[1
]}

BLUMBERG, B ^{[1
]}

ONG, ES ^{[1
]}

BORGMEYER, U ^{[1
]}

MANGELSDORF, DJ ^{[1
]}

UMESONO, K ^{[1
]}

EVANS, RM ^{[1
]}

机构：

[1] HOWARD HUGHES MED INST,LA JOLLA,CA 92037

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 15期

关键词：

NUCLEAR HORMONE RECEPTORS; FATTY ACID; BETA-OXIDATION;

D O I：

10.1073/pnas.91.15.7355

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPAR alpha-related cDNAs (designated PPAR gamma and -delta, respectively) from mouse. The three PPAR isoforms display widely divergent patterns of expression during embryogenesis and in the adult. Surprisingly, PPAR gamma and -delta are not activated by pirinixic acid (Wy 14,643), a potent peroxisome proliferator and activator of PPAR alpha. However, PPAR gamma and -delta are activated by the structurally distinct peroxisome proliferator LY-171883 and linoleic acid, respectively, indicating that each of the isoforms can act as a regulated activator of transcription. These data suggest that tissue-specific responsiveness to peroxisome proliferators, including certain fatty acids, is in part a consequence of differential expression of multiple, pharmacologically distinct PPAR isoforms.

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页码：7355 / 7359

页数：5

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