Third generation beta-blockers: current state of research on vasodilating beta-blockers

被引：0
作者：
Ladage, Dennis [1 ]
Reidenbach, Christian [1 ]
Lichtenthal, Albert [2 ]
Schwinger, Robert [1 ]
Brixius, Klara [1 ]
机构：
[1] Deutsch Sporthochschule Koln, Inst Herz Kreislaufforschung, Abt Mol & Zellulare Sportmed, Am Sportpk Mungersdorf 6, D-50933 Cologne, Germany
[2] Deutsche Fachgesellschaft Neuromentale Med, Essen, Germany
来源：
WIENER MEDIZINISCHE WOCHENSCHRIFT | 2009年 / 159卷 / 7-8期
关键词：
Beta-blocker; nebivolol; hypertension; eNOS; metabolic syndrome;
D O I：
10.1007/s10354-009-0650-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Nebivolol (Nomexor (R)) is a third generation, vasodi-lating beta-blocker with a high beta(1)-adrenoceptor selectivity. Nebivolol acts as an agonist at the beta(3) adrenoceptor as well as the estrogen receptor thereby releasing nitric oxide in blood vessels via eNOS. Pleiotropic effects of nebivolol furthermore include a positive influence on cholesterol and triglycerides and a decrease in thrombocyte activity. Nebivolol is recommended in the guidelines of the European cardiac society (ESC) for patients with metabolic syndrome. Nebivolol's main properties in combination with its broad range of beneficial pleiotropic effects allow it to be clearly distinguished from other second and third generation beta-blockers.
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收藏
页码：211 / 218
页数：8
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