STEM-CELL FACTOR HAS HISTAMINE RELEASING ACTIVITY IN RAT CONNECTIVE TISSUE-TYPE MAST-CELLS

被引：51
作者：
NAKAJIMA, K
HIRAI, K
YAMAGUCHI, M
TAKAISHI, T
OHTA, K
MORITA, Y
ITO, K
机构：
[1] Department of Medicine and Physical Therapy, University of Tokyo School of Medicine, Bunkyo-ku, Tokyo, 113
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 03期
关键词：
D O I：
10.1016/S0006-291X(05)80300-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Stem cell factor (SCF) was documented to be involved in the growth of mast cells controlled by fibroblasts. We tested the effect of recombinant rat SCF on degranulation from rat peritoneal mast cells (connective tissue-type mast cells: CTMC). SCF induced histamine release (∼ 20 % of total histamine content) in a dose-dependent fashion. The release response was relatively rapid and reached a maximum within 5 min. The release showed total dependence on the presence of extracellular phosphatidylserine (PTS). These results reveal that SCF has histamine releasing activity in CTMC. © 1992 Academic Press, Inc.
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页码：1076 / 1083
页数：8
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