EVALUATION OF ANTI-DIABETIC AND HEAPATOPROTECTIVITY OF CORIANDRUM SATIVUM IN ALLOXAN INDUCED EXPERIMENTAL ANIMALS: A HISTOPATHOLOGY STUDY

Objective: Diabetes mellitus is metabolic disorder and day by day number of people increased across the world. The aim of the present study was to evaluate the antidiabetic and heapatoprotectivity of ethanolic extracts of Coriandrum sativum in alloxan induced diabetic rat and find out the harmonious activity of the extract. Methods: The alloxan (150 mg/kg, i.p) used for induction of diabetes after making diabetic model the ethanolic extract of Coriandrum sativum leaves used at a dose of 200 and 400 mg/kg b.w. respectively for single extract treatment for four weeks including metformin (200mg/kg b.w) as a reference drug. The statistical analyses were carried out by one-way ANOVA with post-hoc by Dunnett's Multiple Comparison Test. Results: After 28 days treatment the extracts significantly (p<0.001) reduces serum glucose level and recovered liver function tests (p<0.001) (SGOT, SGPT, ALP and bilirubin) as well glycosylated haemoglobin (p<0.001). Histopathological study showed amelioration in alloxan treated groups. Conclusions: The result suggested that anti-antidiabetic and heapatoprotectivity potential of Coriandrum sativum.