PRIMARY STRUCTURE OF MOUSE TYROSINE-HYDROXYLASE DEDUCED FROM ITS CDNA

被引：58

作者：

ICHIKAWA, S ^{[1
]}

SASAOKA, T ^{[1
]}

NAGATSU, T ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH MED,DEPT BIOCHEM,NAGOYA,AICHI 466,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)90472-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cDNAs for tyrosine hydroxylase were cloned from a mouse brain cDNA library by plaque hybridization. Since the longest cDNA clone lacked approximately 150 bp sequence of its N-terminal region, additional 5′ region was obtained using polymerase chain reaction. Nucleotide sequence determination of cDNAs revealed that mouse tyrosine hydroxylase m-RNA encodes 498 amino acids with a calculated molecular mass of 55990. The amino acid sequence of mouse tyrosine hydroxylase is highly homologus to rat (97%) and human (92%) enzymes. © 1991.

引用

页码：1610 / 1616

页数：7

共 17 条

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