STRAIN-RELATED DIFFERENCES IN AIRWAY SMOOTH-MUSCLE AND AIRWAY RESPONSIVENESS IN THE RAT

被引：43

作者：

EIDELMAN, DH ^{[1
]}

DIMARIA, GU ^{[1
]}

BELLOFIORE, S ^{[1
]}

WANG, NS ^{[1
]}

GUTTMANN, RD ^{[1
]}

MARTIN, JG ^{[1
]}

机构：

[1] MCGILL UNIV,ROYAL VICTORIA HOSP,TRANSPLANTAT SERV,MONTREAL H3A 1A1,QUEBEC,CANADA

来源：

AMERICAN REVIEW OF RESPIRATORY DISEASE | 1991年 / 144卷 / 04期

关键词：

D O I：

10.1164/ajrccm/144.4.792

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The purpose of this study was to evaluate the possible role of the quantity of airway smooth muscle (AWSM) as a determinant of differences in responsiveness between inbred rat strains. To do this, we studied several batches of 8- to 10-wk-old Lewis and Fisher 344 rats. Animals were anesthetized intraperitoneally with pentobarbital (30 mg/kg) and xylazine (7 mg/kg). The peak value of pulmonary resistance (RL) was measured after progressively doubling concentrations of inhaled aerosolized methacholine (MCh). The MCh concentration required to double RL (EC200RL) was calculated as an index of airway responsiveness. Fisher rats were significantly more responsive than Lewis, and the interstrain variability in responsiveness was significantly greater than the intrastrain variability. Additional animals from the less responsive Lewis strain (n = 8) and the more responsive F344 strain (n = 11) were killed immediately after measurement of responsiveness, and AWSM was quantitated as a fraction of total lung tissue using a point-counting technique. F344 rats were again significantly more responsive than Lewis rats (EC200RL geometric mean: 0.72 versus 2.16 mg/ml, p < 0.005). F344 rats also had significantly more AWSM than did Lewis rats (3.22 +/- 0.176 versus 2.48 +/- 0.185%, mean +/- SE, p < 0.001). We conclude that highly inbred Fisher rat strains characteristically exhibit a degree of airways responsiveness greater than that of the Lewis strain and that the quantity of AWSM may be an important determinant of interstrain differences.

引用

页码：792 / 796

页数：5

共 17 条

[1] MECHANICAL ALTERATIONS OF AIRWAY SMOOTH-MUSCLE IN A CANINE ASTHMATIC MODEL [J].

ANTONISSEN, LA ;

MITCHELL, RW ;

KROEGER, EA ;

KEPRON, W ;

TSE, KS ;

STEPHENS, NL .

JOURNAL OF APPLIED PHYSIOLOGY, 1979, 46 (04) :681-687

[2]

ARMOUR CL, 1984, AM REV RESPIR DIS, V129, P907

[3] THE RELATIONSHIP BETWEEN BRONCHIAL HYPERRESPONSIVENESS TO METHACHOLINE AND AIRWAY SMOOTH-MUSCLE STRUCTURE AND REACTIVITY [J].

ARMOUR, CL ;

BLACK, JL ;

BEREND, N ;

WOOLCOCK, AJ .

RESPIRATION PHYSIOLOGY, 1984, 58 (02) :223-233

[4]

BARNES PJ, 1986, AM REV RESPIR DIS, V134, P1289

[5]

BATES JHT, 1990, J APPL PHYSIOL, V89, P995

[6] A COMPARISON OF QUANTITATIVE ANATOMY OF BRONCHI IN NORMAL SUBJECTS IN STATUS ASTHMATICUS IN CHRONIC BRONCHITIS AND IN EMPHYSEMA [J].

DUNNILL, MS ;

MASSARELLA, GR ;

ANDERSON, JA .

THORAX, 1969, 24 (02) :176-+

[7] LATE AIRWAY RESPONSES TO ANTIGEN CHALLENGE IN SENSITIZED INBRED RATS [J].

EIDELMAN, DH ;

BELLOFIORE, S ;

MARTIN, JG .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 137 (05) :1033-1037

[8] AIRWAY RESPONSES IN OFFSPRING OF DOGS WITH AND WITHOUT AIRWAY HYPERREACTIVITY [J].

HIRSHMAN, CA ;

DOWNES, H ;

VEITH, L .

JOURNAL OF APPLIED PHYSIOLOGY, 1984, 56 (05) :1272-1277

[9]

HOSSAIN S, 1973, AM REV RESPIR DIS, V107, P99

[10] THE MECHANICS OF AIRWAY NARROWING IN ASTHMA [J].

JAMES, AL ;

PARE, PD ;

HOGG, JC .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 139 (01) :242-246

← 1 2 →