GENETIC VARIANT OF FACTOR-IX WITH DECREASED CAPACITY FOR CA2+ BINDING

被引：22
作者：
BERTINA, RM
VELTKAMP, JJ
机构：
[1] Haemostasis and Thrombosis Research Unit, Department of Medicine, University Hospital, Leiden
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 1979年 / 42卷 / 04期
关键词：
D O I：
10.1111/j.1365-2141.1979.tb01175.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Summary. A genetic variant of factor IX is described that behaves identically to PIVKA IX (the precursor factor IX molecule induced by the absence of vitamin K or presence of vitamin K antagonists, acarboxy factor IX). It shows an increased electrophoretic mobility in the presence of Ca2+, a low affinity for adsorption to A1(OH)3 and a very low specific coagulant activity. This variant of factor IX has been demonstrated in the plasma of a patient with severe haemophilia B and in the plasmas of a number of possible carriers from the probands’ pedigree. Copyright © 1979, Wiley Blackwell. All rights reserved
引用
收藏
页码：623 / 635
页数：13
相关论文
共 24 条
[1]  
BAJAJ SP, 1975, J BIOL CHEM, V250, P2150
[2]   INHIBITOR-NEUTRALIZATION ASSAY AND ELECTRO-IMMUNO ASSAY OF HUMAN FACTOR-IX (CHRISTMAS FACTOR) [J].
BERTINA, RM ;
VANDERLINDEN, IK .
CLINICA CHIMICA ACTA, 1977, 77 (03) :275-286
[3]  
BERTINA RM, 1978, THROMB HAEMOSTASIS, V40, P335
[4]   LEVELS OF FACTORS II, VII, IX AND X BY ANTIBODY NEUTRALIZATION TECHNIQUES IN PLASMA OF PATIENTS RECEIVING PHENINDIONE THERAPY [J].
DENSON, KWE .
BRITISH JOURNAL OF HAEMATOLOGY, 1971, 20 (06) :643-&
[5]   GAMMA-CARBOXY GLUTAMIC-ACID CONTENT OF HUMAN AND BOVINE PROTHROMBIN FOLLOWING WARFARIN TREATMENT [J].
ESNOUF, MP ;
PROWSE, CV .
BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 490 (02) :471-476
[6]   SPECTRUM OF PARTIALLY CARBOXYLATED PROTHROMBINS IN PLASMAS OF COUMARIN-TREATED PATIENTS [J].
FRIEDMAN, PA ;
ROSENBERG, RD ;
HAUSCHKA, PV ;
FITZJAMES, A .
BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 494 (01) :271-276
[7]  
GANROT PO, 1968, SCAND J CLIN LAB INV, V22, P23
[8]   IMMUNOLOGICAL INVESTIGATION OF HEMOPHILIA-B WITH A TENTATIVE CLASSIFICATION OF DISEASE INTO 5 VARIANTS [J].
GIROLAMI, A ;
STICCHI, A ;
BURUL, A ;
DALBOZANON, R .
VOX SANGUINIS, 1977, 32 (04) :230-238
[9]   .1. GENETIC NOMENCLATURE FOR HUMAN-BLOOD COAGULATION [J].
GRAHAM, JB ;
BARRETT, DA ;
BLOMBACK, B ;
CANN, HM ;
HARDISTY, RM ;
LARRIEU, MJ ;
RENWICK, JH .
THROMBOSIS ET DIATHESIS HAEMORRHAGICA, 1973, 30 (01) :2-11
[10]   STUDIES ON HUMAN FACTOR-IX BY IMMUNOELECTROPHORETIC AND IMMUNODIFFUSION METHODS [J].
HEMMENDORFF, B ;
BORG, H ;
LINDER, A ;
ANDERSSON, LO .
THROMBOSIS RESEARCH, 1978, 12 (01) :131-139
123