STUDIES ON LACTAMAS .55. STEREOSPECIFIC SYNTHESIS AND ANTIBIOTIC-ACTIVITY OF SOME CEPHALOSPORIN ANALOGS

被引：16
作者：
BOSE, AK
RAM, B
HOFFMAN, WA
HUTCHISON, AJ
MANHAS, MS
机构：
[1] Department of Chemistry and Chemical Engineering, Stevens Institute of Technology, Hoboken, New Jersey
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1979年 / 16卷 / 07期
关键词：
D O I：
10.1002/jhet.5570160704
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The strategy used for the stereospecific synthesis of benzofused octams as cepham analogs was the conversion of a 3,4‐dihydrothioisocarbostyril to a thioimidate, cycloaddition reaction to form a fused β‐lactam and subsequent removal of the alkylthio group by Raney nickel hydrogenolysis. Using azidoacetyl chloride for forming the β‐lactam and following known procedures, an amido side chain was generated. Two of the carba analogs of cephalosporin so produced showed low levels of antibacterial activity against a number of gram positive and gram negative organisms. Copyright © 1979 Journal of Heterocyclic Chemistry
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页码：1313 / 1316
页数：4
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