SUSCEPTIBILITY OF CHLAMYDIA-TRACHOMATIS TO ANTIBIOTICS INVITRO AND INVIVO

被引:64
作者
JOHANNISSON, G
SERNRYD, A
LYCKE, E
机构
[1] GOTHENBURG UNIV,INST MED MICROBIOL,DEPT VIROL,S-41346 GOTHENBURG,SWEDEN
[2] SOCIALA HUSET,VENEREAL DIS OUTPATIENT CLIN,GOTEBORG,SWEDEN
关键词
D O I
10.1097/00007435-197904000-00002
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The susceptibility of Chlamydia trac/lOmatis to antibiotics was studied in vitro and in patients with nongonococcal urethritis. The minimal inhibitory concentrations of cloxacillin, erythromycin, pivampicillin, oxytetracycline, and doxycycline, which were the most effective drugs, were 10, 0.5, 0.25, 0.1, and 0.5 μg/ml, respectively. The clinical observations suggested that of the antibiotics studied, doxycycline, erythromycin, and trimethoprim-sulfamethoxazole were effective for treatment of chlamydial infection and nongonococcal urethritis. Trimethoprim-sulfamethoxazole seemed less efficient for treatment of patients with nongonococcal urethritis whose cultures were chlamydia-negative. Pivampicillin, although it was active in vitro against C. trachomatis, did not produce a satisfactory clinical response. Untreated patients had symptoms of urethritis and chlamydial infection for three weeks. Incubation periods of a week or less were recorded for about half of the patients who had nongonococcal urethritis, both those whose cultures were chlamydia-positive and those whose cultures were chlamydia-negative. However, a few patients in both groups reported incubation periods of four weeks or more. © 1979 American Sexually Transmitted Diseases Association.
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页码:50 / 57
页数:8
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