HIV-1 PROTEASE SPECIFICITY OF PEPTIDE CLEAVAGE IS SUFFICIENT FOR PROCESSING OF GAG AND POL POLYPROTEINS

被引：256

作者：

DARKE, PL ^{[1
]}

NUTT, RF ^{[1
]}

BRADY, SF ^{[1
]}

GARSKY, VM ^{[1
]}

CICCARONE, TM ^{[1
]}

LEU, CT ^{[1
]}

LUMMA, PK ^{[1
]}

FREIDINGER, RM ^{[1
]}

VEBER, DF ^{[1
]}

SIGAL, IS ^{[1
]}

机构：

[1] MERCK SHARP & DOHME RES LABS, DEPT MED CHEM, W POINT, PA 19486 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1988年 / 156卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(88)80839-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：297 / 303

页数：7

共 25 条

[1]

COFFIN J, 1982, MOL BIOL TUMOR VIRUS, P261

[2]

COPELAND TD, 1981, PEPTIDES SYNTHESIS S, P497

[3] A DELETION MUTATION IN THE 5' PART OF THE POL GENE OF MOLONEY MURINE LEUKEMIA-VIRUS BLOCKS PROTEOLYTIC PROCESSING OF THE GAG AND POL POLYPROTEINS [J].

CRAWFORD, S ;

GOFF, SP .

JOURNAL OF VIROLOGY, 1985, 53 (03) :899-907

[4]

DARKE PL, UNPUB

[5] HUMAN IMMUNODEFICIENCY VIRUS PROTEASE EXPRESSED IN ESCHERICHIA-COLI EXHIBITS AUTOPROCESSING AND SPECIFIC MATURATION OF THE GAG PRECURSOR [J].

DEBOUCK, C ;

GORNIAK, JG ;

STRICKLER, JE ;

MEEK, TD ;

METCALF, BW ;

ROSENBERG, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (24) :8903-8906

[6] GENOME ORGANIZATION AND TRANSACTIVATION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 [J].

GUYADER, M ;

EMERMAN, M ;

SONIGO, P ;

CLAVEL, F ;

MONTAGNIER, L ;

ALIZON, M .

NATURE, 1987, 326 (6114) :662-669

[7] DIRECT MICROSEQUENCE ANALYSIS OF POLYPEPTIDES USING AN IMPROVED SEQUENATOR, A NON-PROTEIN CARRIER (POLYBRENE), AND HIGH-PRESSURE LIQUID-CHROMATOGRAPHY [J].

HUNKAPILLER, MW ;

HOOD, LE .

BIOCHEMISTRY, 1978, 17 (11) :2124-2133

[8] INHIBITION OF RETROVIRAL PROTEASE ACTIVITY BY AN ASPARTYL PROTEINASE-INHIBITOR [J].

KATOH, I ;

YASUNAGA, T ;

IKAWA, Y ;

YOSHINAKA, Y .

NATURE, 1987, 329 (6140) :654-656

[9] ACTIVE HUMAN IMMUNODEFICIENCY VIRUS PROTEASE IS REQUIRED FOR VIRAL INFECTIVITY [J].

KOHL, NE ;

EMINI, EA ;

SCHLEIF, WA ;

DAVIS, LJ ;

HEIMBACH, JC ;

DIXON, RAF ;

SCOLNICK, EM ;

SIGAL, IS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (13) :4686-4690

[10] SYNTHETIC PEPTIDES AS SUBSTRATES AND INHIBITORS OF A RETROVIRAL PROTEASE [J].

KOTLER, M ;

KATZ, RA ;

DANHO, W ;

LEIS, J ;

SKALKA, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (12) :4185-4189

← 1 2 3 →