CEREBRAL ENERGY-METABOLISM DURING HYPOXEMIA - A P-31 AND H-1 MAGNETIC-RESONANCE STUDY

被引：6

作者：

GARDE, K ^{[1
]}

ROSTRUP, E ^{[1
]}

TOFT, PB ^{[1
]}

HENRIKSEN, O ^{[1
]}

机构：

[1] UNIV COPENHAGEN, DANISH RES CTR MAGNET RESONANCE, COPENHAGEN, DENMARK

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 1995年 / 154卷 / 02期

关键词：

HUMAN CEREBRAL ENERGY METABOLISM; HYPERVENTILATION; HYPOXEMIA; MR SPECTROSCOPY; PCR/P-I-RATIO; PH(I);

D O I：

10.1111/j.1748-1716.1995.tb09900.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

By means of proton and phosphorous magnetic resonance spectroscopy at 1.5 Tesla the human cerebral metabolism was investigated during mild and moderate hypoxaemia. Seven volunteers participated and spectra were obtained while the subjects were breathing atmospheric air, 16, 12 and 10% oxygen in N-2. PaO2, PCO2 and arterial oxygen saturation were determined during the spectroscopic measurements. Haemodynamic and respiratory mechanisms compensated the hypoxic condition and no lactate production was found. There was no change in N-acetyl-aspartate. No change in intracellular pH was found. A slight but non-significant decrease in PCr/P-i-ratio was found, indicating a decrease in the phosphorylation potential of the brain in response to hypoxaemia. The brain sustains aerobic metabolism during mild to moderate hypoxaemia.

引用

页码：185 / 191

页数：7

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