SECRETION OF EPIDERMAL GROWTH-FACTOR BY MACROPHAGES ASSOCIATED WITH BREAST-CARCINOMA

被引：124

作者：

OSULLIVAN, C ^{[1
]}

LEWIS, CE ^{[1
]}

HARRIS, AL ^{[1
]}

MCGEE, JO ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP,INST MOLEC MED,ICRF,CLIN ONCOL UNIT,OXFORD OX3 9DU,ENGLAND

来源：

LANCET | 1993年 / 342卷 / 8864期

关键词：

D O I：

10.1016/0140-6736(93)91348-P

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

By means of a cytokine release assay we have shown that in cell populations derived from primary breast carcinoma, epidermal growth factor (EGF) is secreted by cells with the characteristic morphological and immunophenotypic profile of activated macrophages (positive for CD68, CD16, CD25). EGF secretion was observed in 11 (31%) of 35 primary tumours. Secretion of EGF by normal or malignant epithelial cells was not observed. We found no association between EGF secretion by the primary tumour and recognised clinical indices of prognosis.

引用

页码：148 / 149

页数：2

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