INTERACTIONS BETWEEN SENSORY NEUROPEPTIDES AND LIPID MEDIATORS IN THE AIRWAYS

被引：0
作者：
MANZINI, S
PERRETTI, F
MEINI, S
机构：
[1] IST FARMACOBIOL MALESCI, I-50144 FLORENCE, ITALY
[2] MENARINI PHARMACEUT, DEPT PHARMACOL, I-50131 FLORENCE, ITALY
来源：
JOURNAL OF LIPID MEDIATORS | 1993年 / 8卷 / 02期
关键词：
TACHYKININS; SUBSTANCE-P; NEUROKININ-A; PAF; LIPOXINS; EICOSANOIDS; NEUROGENIC INFLAMMATION; CAPSAICIN; PRIMARY AFFERENT;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The local release of sensory neuropeptides from capsaicin-sensitive primary afferents elicits prominent motor and inflammatory actions in mammalian airways. This neurogenic inflammation can contribute to the pathophysiology of asthma and airway hyperreactivity. In this review evidence will be presented regarding the involvement of this peptidergic neural pathway in the mediation of some pulmonary actions of lipid mediators such as eicosanoids and PAF.
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页码：67 / 79
页数：13
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