PROTECTIVE EFFECT OF NGF ATELOCOLLAGEN MINI-PELLET ON THE HIPPOCAMPAL DELAYED NEURONAL DEATH IN GERBILS

被引：65

作者：

YAMAMOTO, S

YOSHIMINE, T

FUJITA, T

KURODA, R

IRIE, T

FUJIOKA, K

HAYAKAWA, T

机构：

[1] OSAKA UNIV,SCH MED,DEPT NEUROSURG,1-1-50 FUKUSHIMA,OSAKA 553,JAPAN

[2] SUMITOMO PHARMACEUT CO LTD,RES LABS,OSAKA,JAPAN

[3] KINKI UNIV,SCH MED,DEPT NEUROSURG,HIGASHIOSAKA,OSAKA 577,JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 141卷 / 02期

关键词：

NERVE GROWTH FACTOR; DRUG DELIVERY SYSTEM; ATELOCOLLAGEN; DELAYED NEURONAL DEATH; CEREBRAL ISCHEMIA; MONGOLIAN GERBIL;

D O I：

10.1016/0304-3940(92)90885-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Very recently, contradictory results were presented as to the effects of exogenous nerve growth factor (NGF) on the hippocampal delayed neuronal necrosis following transient ischemia. In the present study, we administered a large amount of NGF with the atelocollagen mini-pellet system, measured the local NGF contents, and evaluated the effect of this neurotrophic factor on the postischemic hippocampal pyramidal cells in gerbils. We concluded that the exogenous NGF, when given continuously at sufficient concentrations, prevents pyramidal cell damage. The possible cause of discrepancy in previous studies is discussed.

引用

页码：161 / 165

页数：5

共 25 条

[1] CHRONIC INFUSION OF NERVE GROWTH-FACTOR DOES NOT RESCUE PYRAMIDAL CELLS AFTER TRANSIENT FOREBRAIN ISCHEMIA IN THE RAT [J].