EFFECTS OF MIDAZOLAM ON T-CELL IMMUNOSUPPRESSIVE RESPONSE TO SURGICAL STRESS IN MICE

被引：16

作者：

FREIREGARABAL, M ^{[1
]}

BELMONTE, A ^{[1
]}

BALBOA, JL ^{[1
]}

NUNEZ, MJ ^{[1
]}

机构：

[1] UNIV SANTIAGO COMPOSTELA, FAC MED, DEPT PHARMACOL, SAN FRANCISCO S-N, E-15715 SANTIAGO, SPAIN

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 43卷 / 01期

关键词：

STRESS; IMMUNITY; LYMPHOCYTES-T; BLASTOGENIC RESPONSE; MIDAZOLAM; ANXIOLYTICS; ACTH;

D O I：

10.1016/0091-3057(92)90642-S

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Mice submitted to surgical stress induced by laparotomy and treated with chronic midazolam (1 mg/kg) showed a reduction in stress-induced suppression of thymus and spleen cellularity and in peripheral lymphocyte population. The blastogenic response of spleen lymphoid cells was also assessed and midazolam was found to partially attenuate the suppressive effect of surgery.

引用

页码：85 / 89

页数：5

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