DERACEMIZATION OF AXIALLY DISSYMMETRIC COMPOUNDS BY ENANTIOSELECTIVE DEHYDROHALOGENATION USING CHIRAL LITHIUM AMIDES .2.

被引：16

作者：

DUHAMEL, L

RAVARD, A

PLAQUEVENT, JC

机构：

[1] URA D 0464, UFR Sciences et Techniques, Université de Rouen, F 76134 Mont Saint Aignan Cedex

来源：

TETRAHEDRON-ASYMMETRY | 1990年 / 1卷 / 06期

关键词：

D O I：

10.1016/0957-4166(90)90030-E

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New findings about deracemization of unsaturated carboxylic acids 1 by enantioselective dehydrohalogenation of prochiral species 2 by chiral lithium amides leading to axially dissymmetric compounds with 80% e.e. are reported. The role of the structure of the prochiral hydrochlorinated intermediate is discussed. An example of axial to central chirality transfer is described. (1a → 3). © 1990.

引用

页码：347 / 350

页数：4

共 17 条

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