COLD-INDUCED AND POSTNATAL CHANGES IN BROWN ADIPOSE-TISSUE GANGLIOSIDE LEVELS

被引：4

作者：

KUROSHIMA, A ^{[1
]}

OHNO, T ^{[1
]}

机构：

[1] HOKKAIDO UNIV,NUTR PHYSIOL LAB,ASAHIKAWA 070,JAPAN

来源：

JAPANESE JOURNAL OF PHYSIOLOGY | 1990年 / 40卷 / 01期

关键词：

D O I：

10.2170/jjphysiol.40.57

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Effects of cold and postnatal development were studied on brown adipose tissue (BAT) ganglioside levels in rats. Interscapular BAT was defatted by cold acetone before ganglioside extraction. Gangliosides were determined using HPTLC. Major ganglioside in BAT was found to be GM3. BAT GM3 level per g of fresh tissue weight as well as fat-free dry matter significantly increased in cold-acclimated rats (CA) and in rats reared in cold for 27 generations. BAT GM3 level per g of fresh weight as well as fat-free dry matter was significantly higher in 4-day- and 14-day-old rats than that in adult animals (12 weeks old). It was also shown that the higher levels of BAT GM3 were associated with greater BAT weight relative to body weight. These results suggest that BAT ganglioside, especially GM3, is implicated in growth and/or function of BAT in terms of cold-induced and postnatal changes of this tissue.

引用

页码：57 / 64

页数：8

共 24 条

[1] CHANGES IN INTERSCAPULAR BROWN ADIPOSE TISSUE OF RAT DURING PERINATAL AND EARLY POSTNATAL DEVELOPMENT AND AFTER COLD ACCLIMATION .1. ACTIVITIES OF SOME RESPIRATORY ENZYMES IN TISSUE [J].