ACTIVITY OF ANTI-TUMOR DRUGS AGAINST AFRICAN TRYPANOSOMES

Of 49 compounds known to have antitumor properties, 6 were found to have significant activity against Trypanosoma rhodesiense infections in mice. Activity against the African tripanosomes has not been reported previously for any of these six compounds. In order of decreasing activity these compounds were: imidazole-4-carboxamide, 5-(3,3-dimethyl-1,1-triazene), inosine diglycolaldehyde, cis-diamminedichloro-platinum, streptozotocin, coralyne sulfate, and 5-fluoro-2'-deoxyuridine. The percentage of 'hits' (12.2%) from these known antitumor agents was approximately twice as great as when other means are employed for the selection of compounds for this test system.