Intestinal microbiota, chronic inflammation, and colorectal cancer

被引：80

作者：

Park, Chan Hyuk ^{[1
]}

Eun, Chang Soo ^{[1
]}

Han, Dong Soo ^{[1
]}

机构：

[1] Hanyang Univ, Guri Hosp, Coll Med, Dept Internal Med, 153 Gyeongchun Ro, Guri 11923, South Korea

来源：

INTESTINAL RESEARCH | 2018年 / 16卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Microbiota; Colorectal neoplasms; Carcinogenesis; Inflammation;

D O I：

10.5217/ir.2018.16.3.338

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In addition to genetic and epigenetic factors, various environmental factors, including diet, play important roles in the development of colorectal cancer (CRC). Recently, there is increasing interest in the intestinal microbiota as an environmental risk factor for CRC, because diet also influences the composition of the intestinal microbiota. The human intestinal microbiota comprises about 100 trillion microbes. This microbiome thrives on undigested dietary residues in the intestinal lumen and produces various metabolites. It is well known that the dietary risk factors for CRC are mediated by dysbiosis of the intestinal microbiota and their metabolites. In this review, we describe the bacterial taxa associated with CRC, including Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, Escherichia coli, and butyrate-producing bacteria. We also discuss the host-diet interaction in colorectal carcinogenesis.

引用

页码：338 / 345

页数：8

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