TUMOR INHIBITORS .43. SOLAPALMITINE AND SOLAPALMITENINE, 2 NOVEL ALKALOID TUMOR INHIBITORS FROM SOLANUM TRIPARTITUM

被引：35
作者：
KUPCHAN, SM
DAVIES, AP
BARBOUTIS, SJ
SCHNOES, HK
BURLINGAME, AL
机构：
[1] Department of Pharmaceutical Chemistry, University of Wisconsin, Madison
[2] Space Sciences Laboratory, Department of Chemistry, University of California, Berkeley
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1969年 / 34卷 / 12期
关键词：
D O I：
10.1021/jo01264a031
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An alcoholic extract of Solanum tripartitum Dunal was found to show significant inhibitory activity when tested in vitro against cells derived from human carcinoma of the nasopharynx (KB). Systematic fractionation led to the separation of solapartine, a liquid alkaloid mixture which possessed significant inhibitory activity against the Walker 256 carcinosarcoma in rats. Further fractionation of solapartine resulted in the separation of two growth-inhibitory compounds, solapalmitine and solapalmitenine. A combination of chemical degradations, mass spectrometry, and total synthesis led to assignment of structure 9 for solapalmitine and 11 for solapalmitenine. © 1969, American Chemical Society. All rights reserved.
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页码：3888 / +
页数：1
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