IN-VITRO BIOCOMPATIBILITY EVALUATION OF A HEPARINIZABLE MATERIAL (PUPA), BASED ON POLYURETHANE AND POLY(AMIDO-AMINE) COMPONENTS

被引：43

作者：

ALBANESE, A

BARBUCCI, R

BELLEVILLE, J

BOWRY, S

ELOY, R

LEMKE, HD

SABATINI, L

机构：

[1] BIOMATECH,ZONE IND ISLON,F-38670 CHASSE SUR RHONE,FRANCE

[2] AKZO FABER AG,ARLO,W-8153 OBERNBURG,GERMANY

[3] NUOVO POLICLIN LE SCOTTE,USL LAB 30,I-53100 SIENA,ITALY

来源：

BIOMATERIALS | 1994年 / 15卷 / 02期

关键词：

HEPARINIZATION; BIOCOMPATIBILITY; CELL CULTURE; STERILIZATION;

D O I：

10.1016/0142-9612(94)90262-3

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The biocompatibility of a new heparinizable material based on polyurethane and poly(amido-amine) (PUPA) was evaluated both in the heparinized and non-heparinized forms. The quantity of heparin present on the material was measured using radiolabelled heparin and biological tests. Heparin release in plasma from heparinized PUPA was investigated using in vitro methods. The behaviour of PUPA towards cellular and plasmatic blood components was studied. The influence of sterilization on the cytocompatibility response of both heparinized acid non-heparinized PUPA was investigated; gamma-rays were found to be a suitable method of sterilization as no toxic response was noticed.

引用

页码：129 / 136

页数：8

共 16 条

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