A NEW APPROACH TO THE SYNTHESIS OF BETA-FLUOROPYRROLE DERIVATIVES

被引：25
|
作者：
QIU, ZM [1 ]
BURTON, DJ [1 ]
机构：
[1] UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 25期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/S0040-4039(00)73343-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
beta-Fluoropyrrole derivatives are synthesized in high yields by the reaction of alpha,alpha-difluoro-gamma-iodo-gamma-(electron-withdrawing-group)-substituted ketones and ammonium hydroxide at room temperature; providing a new, simple, and efficient method for the synthesis of beta-fluorinated pyrrole rings. A possible mechanism is proposed.
引用
收藏
页码：4319 / 4322
页数：4
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