A NEW APPROACH TO THE SYNTHESIS OF BETA-FLUOROPYRROLE DERIVATIVES

被引：25
|
作者：
QIU, ZM [1 ]
BURTON, DJ [1 ]
机构：
[1] UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 25期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/S0040-4039(00)73343-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
beta-Fluoropyrrole derivatives are synthesized in high yields by the reaction of alpha,alpha-difluoro-gamma-iodo-gamma-(electron-withdrawing-group)-substituted ketones and ammonium hydroxide at room temperature; providing a new, simple, and efficient method for the synthesis of beta-fluorinated pyrrole rings. A possible mechanism is proposed.
引用
收藏
页码：4319 / 4322
页数：4
相关论文
共 50 条
  • [31] A NEW APPROACH TO TERTIARY BETA-CHLOROALKYLAMINES - SYNTHESIS OF BETA-CHLOROALKYLAMINOMETHYLHYDROQUINONES
    WEATHERBEE, C
    TEMPLE, R
    BURKE, WJ
    JOURNAL OF ORGANIC CHEMISTRY, 1956, 21 (10): : 1138 - 1141
  • [32] EMPLOYMENT OF A STEROIDAL ALDEHYDE IN A NEW SYNTHESIS OF BETA-LACTAM DERIVATIVES
    DOMLING, A
    KEHAGIA, K
    UGI, I
    TETRAHEDRON, 1995, 51 (35) : 9519 - 9522
  • [33] SYNTHESIS OF NEW INDENE DERIVATIVES WITH BETA-ADRENERGIC BLOCKING PROPERTIES
    MURASE, K
    MURAKAMI, M
    NIIGATA, K
    MASE, T
    YAKUGAKU ZASSHI, 1972, 92 (11): : 1358 - &
  • [34] A NEW SYNTHESIS OF INDOLO[3,2-BETA]INDOLE DERIVATIVES
    GRINYOV, AN
    RYABOVA, SY
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1982, (02): : 199 - 200
  • [35] A NEW APPROACH TO THE SYNTHESIS OF 1,6-ANHYDRO-2-AZIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE DERIVATIVES
    KLOOSTERMAN, M
    DENIJS, MP
    VANBOOM, JH
    RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS-JOURNAL OF THE ROYAL NETHERLANDS CHEMICAL SOCIETY, 1984, 103 (7-8): : 243 - 244
  • [36] A facile tandem carbene-ylide route to 2-fluoropyrrole derivatives
    Novikov, MS
    Khlebnikov, AF
    Sidorina, ES
    Kostikov, RR
    JOURNAL OF FLUORINE CHEMISTRY, 1998, 90 (02) : 117 - 119
  • [37] A new approach to the synthesis of 3,4-dihydroisocoumarin derivatives
    Obushak, Mykola D.
    Matiychuk, Vasyl S.
    Turytsya, Victor V.
    TETRAHEDRON LETTERS, 2009, 50 (45) : 6112 - 6115
  • [38] A New Highly Efficient Approach to the Synthesis of Coumarin and its Derivatives
    Hojati, Seyedeh Fatemeh
    Hadadnia, Zahra
    JORDAN JOURNAL OF CHEMISTRY, 2016, 11 (01) : 1 - 7
  • [39] ACTIVATED NITRILES IN HETEROCYCLIC SYNTHESIS - A NEW APPROACH FOR THE SYNTHESIS OF PYRIDINE AND PYRIDINOPYRIMIDINE DERIVATIVES
    ABDELRAZEK, FM
    IBRAHIM, NS
    KANDEEL, ZE
    ELNAGDI, MH
    SYNTHESIS-STUTTGART, 1984, (11): : 970 - 972
  • [40] New approach to the synthesis of lysophosphatidic acid and related lysophospholipid derivatives
    Hajdu, J
    Rosseto, R
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U164 - U165
12345